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24px;display:flex}.bmap-lede{max-width:62ch;color:var(--tatl-mute,var(--brand-ink-muted));margin-top:6px;font-size:13px;line-height:1.5}.bmap-switch{scrollbar-width:none;max-width:100%;overflow-x:auto}.bmap-stage{gap:24px;display:grid}@media (min-width:900px){.bmap-stage{grid-template-columns:minmax(0,1.4fr) minmax(0,1fr);align-items:start}}.bmap-figures{grid-template-columns:1.55fr 1fr .4fr;align-items:end;gap:12px;display:grid}.bmap-fig{flex-direction:column;align-items:center;gap:6px;min-width:0;margin:0;display:flex}.bmap-svg{fill:none;stroke-linecap:round;width:100%;height:auto;overflow:visible}.bmap-fig-cap{color:var(--tatl-mute,var(--brand-ink-muted));text-align:center;font-size:11px;line-height:1.3}.bmap-tissue{stroke:color-mix(in oklab, var(--brand-ink) 11%, transparent);stroke-width:3px}.bmap-base{stroke:color-mix(in oklab, var(--brand-ink) 24%, transparent);stroke-width:3px}.bmap-band{stroke:var(--brand-accent);stroke-width:4.4px;opacity:0;transition:opacity var(--duration-slow) var(--ease-out), transform var(--duration-slow) var(--ease-out);transition-delay:calc(var(--k) * 70ms);transform:scale(.55)}.bmap-region[data-lit] .bmap-band{opacity:1;transform:none}.bmap-region[data-lit=present] .bmap-band{opacity:.5}.bmap[data-focus] .bmap-region[data-lit]:not([data-focus]) .bmap-band{opacity:.2}.bmap-target{flex-wrap:wrap;align-items:baseline;gap:4px 10px;display:flex}.bmap-target-name{letter-spacing:-.02em;font-size:22px;font-weight:600}.bmap-target-count{color:var(--tatl-mute,var(--brand-ink-muted));font-size:12px}.bmap-sites{border-top:1px solid var(--tatl-line,var(--brand-rule));margin:10px 0 0;padding:0;list-style:none}.bmap-site{border-bottom:1px solid var(--tatl-line,var(--brand-rule));transition:background-color var(--duration-quick) var(--ease-out);grid-template-columns:minmax(0,1fr) auto;gap:2px 10px;padding:10px 6px;display:grid}@media (hover:hover){.bmap-site:hover{background:color-mix(in oklab, var(--brand-ink) 4%, transparent)}}.bmap-site-region{font-size:14px;font-weight:500}.bmap-site-level{border-radius:var(--radius-lozenge);background:color-mix(in oklab, var(--brand-ink) 6%, var(--tatl-slab,var(--brand-paper)));justify-self:end;padding:1px 8px;font-size:11px;line-height:18px}.bmap-site[data-level=high] .bmap-site-level{background:color-mix(in oklab, var(--brand-accent) 24%, var(--tatl-slab,var(--brand-paper)))}.bmap-site-label{color:var(--tatl-mute,var(--brand-ink-muted));grid-column:1/-1;font-size:13px;line-height:1.45}.bmap-site-ref a{color:var(--brand-ink);font-family:var(--font-favorit-mono);border-radius:4px;margin-left:3px;font-size:10px;text-decoration:none}.bmap-sources{color:var(--tatl-mute,var(--brand-ink-muted));font-size:12px;line-height:1.5}.bmap-sources-title{color:var(--brand-ink);margin-bottom:6px;font-weight:500}.bmap-sources ol{gap:4px;margin:0;padding-left:18px;display:grid}.bmap-sources a{color:inherit;text-decoration:underline;-webkit-text-decoration-color:var(--brand-rule);text-decoration-color:var(--brand-rule);text-underline-offset:3px;border-radius:4px}@media (hover:hover){.bmap-sources a:hover{text-decoration-color:currentColor}}@media (forced-colors:active){.rxn-mark,.bmap-band{forced-color-adjust:none}.rxn-mark[data-cls=activate],.rxn-mark[data-cls=block]{background:highlight}.bmap-band{stroke:highlight}}.tfc-wide{grid-column:1/-1;min-width:0}.hatl{margin-top:56px}@media (min-width:768px){.hatl{margin-top:80px}}.hatl-lede{max-width:60ch;color:var(--tatl-mute);margin-top:12px;font-size:15px;line-height:1.5}.hatl-stage{--hatl-spread:44%;aspect-ratio:1;width:100%;max-width:920px;margin-inline:auto;position:relative}@media (min-width:640px){.hatl-stage{--hatl-spread:50%;aspect-ratio:2.4}}.hatl-hub{min-width:96px;height:56px}.hatl-hub-name{letter-spacing:-.02em;animation:hatl-swap var(--duration-slow) var(--ease-out) both;font-size:20px;font-weight:600}@keyframes hatl-swap{0%{opacity:0;transform:scale(.9)}}.hatl-node{top:calc(50% + var(--uy) * var(--hatl-spread));left:calc(50% + var(--ux) * var(--hatl-spread));z-index:3;border-radius:var(--radius-soft);background:var(--brand-paper);box-shadow:0 0 0 1px var(--tatl-line);color:var(--brand-ink);font:inherit;cursor:pointer;transition:opacity var(--duration-fast) var(--ease-out), transform var(--duration-fast) var(--ease-out);border:0;flex-direction:column;align-items:center;gap:1px;padding:4px 8px;display:inline-flex;position:absolute;translate:-50% -50%}.hatl-node[data-on]{transform:scale(1.05)}@media (min-width:640px){.hatl-node{padding:6px 12px}.hatl-node-name{font-size:14px}}.hatl-node:active{transform:scale(.97)}.hatl-node[aria-checked=true]{background:var(--brand-ink);color:var(--brand-paper)}.hatl-stage[data-hot] .hatl-node:not([data-on]){opacity:.55}.hatl-node-name{white-space:nowrap;font-size:13px;font-weight:500;line-height:18px}.hatl-node-count{color:var(--tatl-mute);font-family:var(--font-favorit-mono);white-space:nowrap;font-variant-numeric:tabular-nums;font-size:10px;line-height:14px}@media (max-width:767.98px){.hatl-node-count,.bmap-site-ref a{font-size:11px}}.hatl-node-count-full,.hatl-node-count[aria-hidden]+.hatl-node-count-full{clip-path:inset(50%);white-space:nowrap;width:1px;height:1px;position:absolute;overflow:hidden}@media (min-width:640px){.hatl-node-count[aria-hidden]{display:none}.hatl-node-count[aria-hidden]+.hatl-node-count-full{clip-path:none;width:auto;height:auto;position:static;overflow:visible}}.hatl-node[aria-checked=true] .hatl-node-count{color:color-mix(in oklab, var(--brand-paper) 72%, transparent)}.hatl-stage .rxn-hub{z-index:2}.hatl-packet{stroke:var(--brand-accent)}.hatl-top{flex-direction:column;gap:10px;display:flex}.hatl-top-title{font-size:13px;font-weight:500}.hatl-top ol{flex-wrap:wrap;gap:8px;margin:0;padding:0;list-style:none;display:flex}.hatl-top-link{border-radius:var(--radius-lozenge);background:var(--brand-paper);color:var(--brand-ink);transition:transform var(--duration-quick) var(--ease-out);align-items:baseline;gap:8px;padding:6px 12px;text-decoration:none;display:inline-flex}.hatl-top-link:active{transform:scale(.97)}.hatl-top-symbol{font-size:14px;font-weight:500}.hatl-top-value{color:var(--tatl-mute);font-family:var(--font-favorit-mono);font-variant-numeric:tabular-nums;font-size:11px}.wkc{--wkc-slab:var(--brand-paper-tint);--wkc-mute:var(--brand-ink-muted);--wkc-line:color-mix(in oklab, var(--brand-ink) 13%, transparent);--tatl-slab:var(--wkc-slab);--tatl-line:var(--wkc-line);border-radius:var(--radius-lg);background:var(--wkc-slab);min-width:0;color:var(--brand-ink);padding:20px}@media (min-width:768px){.wkc{padding:24px}}@media (min-width:1024px){.wkc{padding:28px}}.wkc-head{justify-content:space-between;align-items:flex-start;gap:16px;display:flex}.wkc-title{font-family:var(--font-montreal);letter-spacing:-.015em;text-wrap:balance;font-size:19px;font-weight:500;line-height:1.25}@media (min-width:768px){.wkc-title{font-size:22px}}.wkc-sub{color:var(--wkc-mute);margin-top:4px;font-size:13px;line-height:1.45}.wkc-body{margin-top:18px}@media (min-width:768px){.wkc-body{margin-top:22px}}.wkc .border-rule{border-color:var(--wkc-line)}.wkc-chip{border-radius:var(--radius-lozenge);background:var(--brand-paper);font-family:var(--font-montreal);align-items:center;padding:5px 12px;font-size:13px;font-weight:500;line-height:18px;display:inline-flex}@media (min-width:768px){.wkc-chip{font-size:14px}}.wkc .tatl{background:0 0;border-radius:0;padding:0}.wkc-figure{min-width:0}.wkc-notice{padding-block:18px}.wkc-notice+.wkc,.wkh-lead>.wkc+.wkc{margin-top:12px}.wkh{flex-direction:column;gap:12px;padding-top:20px;display:flex}@media (min-width:1024px){.wkh{grid-template:"plate lead""plate simple"1fr/minmax(0,7fr) minmax(0,5fr);gap:12px;padding-top:28px;display:grid}.wkh-lead{grid-area:lead}.wkh-plate{grid-area:plate}.wkh-simple{grid-area:simple}}.wkh-id .fiche-symbol{font-size:clamp(4rem,14vw,7.5rem)}.wkh-id .fiche-symbol[data-len=m]{font-size:clamp(2.75rem,8vw,4.75rem)}.wkh-id .fiche-symbol[data-len=l]{font-size:clamp(2.125rem,5.5vw,3.375rem)}.wkh-name{font-family:var(--font-montreal);letter-spacing:-.01em;text-wrap:pretty;margin-top:14px;font-size:20px;font-weight:500;line-height:1.2;display:block}@media (min-width:768px){.wkh-name{font-size:24px}}.wkh-lede{text-wrap:pretty;max-width:52ch;margin-top:16px;font-size:17px;line-height:1.5}.wkh-foot{border-top:1px solid var(--wkc-line);flex-wrap:wrap;justify-content:space-between;align-items:center;gap:16px 24px;margin-top:22px;padding-top:18px;display:flex}.wkh-molecule{flex-direction:column;gap:8px;display:flex}.wkh-molecule-head{justify-content:space-between;align-items:flex-start;gap:16px;display:flex}.wkh-accession{color:var(--wkc-mute);font-family:var(--font-favorit-mono);text-align:right;font-variant-numeric:tabular-nums;padding-top:6px;font-size:12px}.wkh-specimen{--wkh-mol-h:10rem;width:min(100%, calc(var(--wkh-mol-h) * var(--mol-ratio,2)));align-self:center;margin-block:auto;padding-block:20px 28px}.wkh-specimen svg{max-height:var(--wkh-mol-h)}@media (min-width:768px){.wkh-specimen{--wkh-mol-h:17rem;padding-block:28px 36px}}.wkh-label{border-top:1px solid var(--wkc-line);margin-top:auto;padding-top:14px}.wkh-plain{text-wrap:pretty;margin-top:14px;font-size:16px;line-height:1.6}.wkh-plain-muted{color:var(--wkc-mute)}.wkb{flex-direction:column;gap:12px;padding-bottom:12px;display:flex}.wkb-rail{padding:16px 20px}.wkp{padding-top:52px}.wkp-sheet{width:100%;max-width:17rem;transition:transform var(--duration-quick) var(--ease-out);flex-direction:column;gap:12px;display:flex}.wkp-sheet:active{transform:scale(.98)}.wkp-sheet.items-end{margin-left:auto}.wkp-molecule{aspect-ratio:4/3;justify-content:center;align-items:center;width:100%;padding:8px;display:flex}.wkc-hubtitle{font-family:var(--font-montreal);letter-spacing:-.025em;text-wrap:balance;color:var(--brand-ink);font-size:28px;font-weight:500;line-height:1.08}@media (min-width:768px){.wkc-hubtitle{font-size:36px}}@media (min-width:1024px){.wkc-hubtitle{font-size:40px}}.wiki-origin-section{--wkc-line:color-mix(in oklab, var(--brand-ink) 13%, transparent);border-radius:var(--radius-lg);background:var(--brand-paper-tint);padding:20px}@media (min-width:768px){.wiki-origin-section{padding:28px}}@media (min-width:1024px){.wiki-origin-section{padding:36px}}.wiki-origin-section+.wiki-origin-section{margin-top:12px}@media (min-width:48rem){.wiki-origin-section+.wiki-origin-section{margin-top:12px}}.wiki-origin-section .border-rule{border-color:var(--wkc-line)}.wiki-origin-section .wiki-tile{background-color:var(--brand-paper)}.wiki-map-card{padding:16px 18px;display:flex}.wiki-map-card>a{flex:1;padding-top:0}.wkc-article{padding-block:28px}@media (min-width:1024px){.wkc-article{padding:40px}}.wkc-hero{padding-block:28px}@media (max-width:767.98px){.wkc-hero{padding-block:16px}}@media (min-width:1024px){.wkc-hero{padding:40px}.wkh-missing{grid-template-rows:auto;grid-template-areas:"plate lead"}}:is(.wkc,.tatl,.tfc-card,.wiki-origin-section){--tab-rail:var(--tab-rail-on-tint)}