{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"LMENRXZOUBANKQ-UHFFFAOYSA-N","prefName":"CHM-081","symbol":"CHM-081","iupacName":"[1-(cyclohexylmethyl)indol-3-yl]-(4-methoxynaphthalen-1-yl)methanone","aliases":["CHM-081","1-(cyclohexylmethyl)-3-(4-methoxy-1-naphthoyl)indole"],"cas":"1373876-34-6","pubchemCid":"118796420","chebiId":null,"smiles":"COC1=CC=C(C2=CC=CC=C21)C(=O)C3=CN(C4=CC=CC=C43)CC5CCCCC5","molecularFormula":"C27H27NO2","molecularWeight":397.5,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/118796420"}},"classification":{"family":"scra","familyLabel":"Synthetic cannabinoid (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (pharmaceutical research → illicit market)","summaryFr":"No biosynthetic route is described: CHM-081 belongs to synthetic chemistry, through attachment of a naphthoyl group at position 3 of an indole substituted on the nitrogen.","originNote":"Synthetic molecule: no source consulted reports it in a plant or a living organism. It has been reported in seized plant material packaged as herbal incense.","discovered":""},"pharmacology":{"summaryFr":"CHM-081 is a synthetic molecule of the naphthoylindole family, an analogue of JWH-081 in which the pentyl chain is replaced by a cyclohexylmethyl group. Blakey et al. (2016) report it in seized plant material packaged as herbal incense. The sources consulted give no affinity constant for CB1 or CB2, and no human pharmacokinetic or toxicological data. Its status in France rests on the generic clause of the indol-3-yl methanone family, not on a named mention.","receptorSummaryFr":"No affinity constant or activity measurement on CB1 or CB2 is published for this compound in the sources consulted. Blakey et al. (2016) describe it as an analogue of JWH-081 from which it differs only by the substituent on the indole nitrogen. Agonist activity is presumed by structural analogy, without direct measurement. No data measured on JWH-081 should therefore be attributed to CHM-081 without verification.","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":5,"reported":"Aucune constante d'affinité publiée ; agonisme présumé par analogie avec le JWH-081, non mesuré pour ce composé","confidence":"medium"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":5,"reported":"Aucune constante d'affinité publiée ; agonisme présumé par analogie avec le JWH-081, non mesuré pour ce composé","confidence":"medium"}],"references":[{"label":"Blakey K. et coll., identification du QMPSB et d'autres drogues de synthèse dans les mélanges à fumer (herbal incense), Forensic Science International, 2016","pmid":"26795397","doi":"10.1016/j.forsciint.2015.12.001","url":"https://pubmed.ncbi.nlm.nih.gov/26795397/"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026, annexe IV, famille des indol-3-yl méthanones","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Green List 2026 (substances des conventions de 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CID 118796420, [1-(cyclohexylmethyl)indol-3-yl]-(4-methoxynaphthalen-1-yl)methanone","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/118796420"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":5},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":5},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":5},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":5},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":5}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"controlled-clause","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonised control measure at European Union level has been identified for this compound in the sources consulted. Control therefore currently falls under the national legislation of member states. At international level, it is not named in the INCB Green List 2026 (annexes of the 1971 Convention).","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Substance classified as a narcotic in France through the generic clause of its family, without being named individually. The ANSM consolidated list of 16 February 2026 (annex IV) defines the family of indol-3-yl methanones: a substituent on the indole nitrogen of cycloalkylmethyl type, and a naphthyl group, substituted or not, on the carbon of the methanone bridge. CHM-081 meets both conditions. JWH-081, of which it is the analogue with the N-pentyl chain replaced by a cyclohexylmethyl group, is named in the same annex, which is not the case for CHM-081.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Blakey K. et coll., identification du QMPSB et d'autres drogues de synthèse dans les mélanges à fumer (herbal incense), Forensic Science International, 2016","pmid":"26795397","doi":"10.1016/j.forsciint.2015.12.001","url":"https://pubmed.ncbi.nlm.nih.gov/26795397/"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026, annexe IV, famille des indol-3-yl méthanones","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Green List 2026 (substances des conventions de 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CID 118796420, [1-(cyclohexylmethyl)indol-3-yl]-(4-methoxynaphthalen-1-yl)methanone","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/118796420"}],"meta":{"slug":"chm-081","url":"https://en.phytogrammes.com/wiki/chm-081","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}