{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"MSJISJDTJJYBFT-UHFFFAOYSA-N","prefName":"COR170","symbol":"COR170","iupacName":"N-(1-adamantyl)-4-oxo-1-pentyl-6-phenylquinoline-3-carboxamide","aliases":["COR 170","COR-170"],"cas":null,"pubchemCid":"25033736","chebiId":null,"smiles":"CCCCCN1C=C(C(=O)C2=C1C=CC(=C2)C3=CC=CC=C3)C(=O)NC45CC6CC(C4)CC(C6)C5","molecularFormula":"C31H36N2O2","molecularWeight":468.6,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/25033736"}},"classification":{"family":"ecs_tool","familyLabel":"ECS modulator (research)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (research tool)","summaryFr":"No biosynthetic pathway: a chemically synthesised molecule, obtained by the methods of amide chemistry applied to the 4-quinolone-3-carboxamide series.","originNote":"Fully synthetic molecule, from the 4-quinolone-3-carboxamide series developed at the University of Siena (Italy) by the team of F. Corelli and S. Pasquini (Pasquini et al., 2008). No source consulted describes its presence in a plant.","discovered":""},"pharmacology":{"summaryFr":"COR170 is a synthetic quinolone-3-carboxamide, systematic name N-(1-adamantyl)-4-oxo-1-pentyl-6-phenylquinoline-3-carboxamide, whose structure is registered under this code in PubChem (CID 25033736). Its affinity for the CB2 receptor is a Ki of 3.8 nM, against more than 10 000 nM for CB1 (Pasquini et al., 2008; ChEMBL). The studies that use the code COR170 describe it as a CB2 antagonist or inverse agonist: at 1 nM, it abolishes the effects of COR167, a related CB2 agonist, on glutamate and LDH release from rat brain cortical slices (Contartese et al., 2012), and at 10 µM, alone, it reduces IL-6 production by synovial fibroblasts from patients with rheumatoid arthritis (Lowin et al., 2016). The publications cited name the molecule only by its code: the match with this structure rests on PubChem and ChEMBL. COR167 carries an isopropyl group at position 6 and is a different molecule (Borgonetti et al., 2023). No published human data has been found.","receptorSummaryFr":"Antagonist or inverse agonist at the CB2 cannabinoid receptor. An inhibition constant Ki of 3.8 nM at CB2 is reported for this structure, against more than 10 000 nM at CB1, and a CB2/CB1 selectivity ratio above 2 666 (Pasquini et al., 2008; ChEMBL). In studies that use the code COR170, the molecule blocks the effect of a CB2 agonist: at 1 nM, it abolishes the effects of COR167 on glutamate and LDH release (Contartese et al., 2012).","binding":[{"target":"CB2","efficacy":"inverse_agonist","relativeActivity":88,"reported":"Ki 3,8 nM sur le CB2 ; Ki supérieur à 10 000 nM sur le CB1 (Pasquini et coll., 2008 ; ChEMBL)","confidence":"medium"}],"references":[{"label":"Pasquini et coll., motif acide 4-quinolone-3-carboxylique (2), J Med Chem, 2008","pmid":"18680276","doi":"10.1021/jm800552f","url":"https://pubmed.ncbi.nlm.nih.gov/18680276/"},{"label":"Contartese et coll., effet protecteur du COR167 sur tranches corticales de rat, Pharmacol Res, 2012","pmid":"23036353","doi":"10.1016/j.phrs.2012.08.003","url":"https://pubmed.ncbi.nlm.nih.gov/23036353/"},{"label":"Lowin et coll., WIN55,212-2 et fibroblastes synoviaux de polyarthrite rhumatoïde, J Inflamm (Lond), 2016","pmid":"27158245","doi":"10.1186/s12950-016-0114-7","url":"https://pubmed.ncbi.nlm.nih.gov/27158245/"},{"label":"Borgonetti et coll., le COR167 et la douleur neuropathique chez la souris, Biomedicines, 2023","pmid":"37371642","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/37371642/"},{"label":"ChEMBL, notice CHEMBL523577 (affinités CB1 et CB2)","pmid":null,"doi":null,"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL523577/"},{"label":"PubChem, notice du composé COR170 (CID 25033736)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/25033736"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Green List 2026 (annexes des conventions de 1961 et 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":5},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":2},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":2},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":2},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":2}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"unscheduled","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonised control measure at European Union level has been identified in the sources consulted. Any control therefore falls under the national legislation of the Member States.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"COR170 is not named in any annex of the French narcotics list (ANSM consolidated list, updated 16 February 2026). Its structure, a 4-quinolone-3-carboxamide, meets none of the family definitions of that list: they target derivatives of indole, indazole, pyrrole, pyrrolo[3,2-c]pyridine or thiazole, cyclohexylphenols and the benzo[c]chromene nucleus, and none covers the 4-quinolone. It is therefore not captured and remains unscheduled in France, which does not mean that its sale or use is authorised.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Pasquini et coll., motif acide 4-quinolone-3-carboxylique (2), J Med Chem, 2008","pmid":"18680276","doi":"10.1021/jm800552f","url":"https://pubmed.ncbi.nlm.nih.gov/18680276/"},{"label":"Contartese et coll., effet protecteur du COR167 sur tranches corticales de rat, Pharmacol Res, 2012","pmid":"23036353","doi":"10.1016/j.phrs.2012.08.003","url":"https://pubmed.ncbi.nlm.nih.gov/23036353/"},{"label":"Lowin et coll., WIN55,212-2 et fibroblastes synoviaux de polyarthrite rhumatoïde, J Inflamm (Lond), 2016","pmid":"27158245","doi":"10.1186/s12950-016-0114-7","url":"https://pubmed.ncbi.nlm.nih.gov/27158245/"},{"label":"Borgonetti et coll., le COR167 et la douleur neuropathique chez la souris, Biomedicines, 2023","pmid":"37371642","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/37371642/"},{"label":"ChEMBL, notice CHEMBL523577 (affinités CB1 et CB2)","pmid":null,"doi":null,"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL523577/"},{"label":"PubChem, notice du composé COR170 (CID 25033736)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/25033736"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Green List 2026 (annexes des conventions de 1961 et 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"}],"meta":{"slug":"cor170","url":"https://en.phytogrammes.com/wiki/cor170","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}