{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"CGHCGYCTOLWAPL-UHFFFAOYSA-N","prefName":"CUMYL-CH-MEGACLONE","symbol":"CUMYL-CH-MEGACLONE","iupacName":"5-(cyclohexylmethyl)-2-(2-phenylpropan-2-yl)pyrido[4,3-b]indol-1-one","aliases":["SGT-270","SGT270","Cumyl-cyclohexyl-pegaclone"],"cas":null,"pubchemCid":"155884822","chebiId":null,"smiles":"CC(C)(C1=CC=CC=C1)N2C=CC3=C(C2=O)C4=CC=CC=C4N3CC5CCCCC5","molecularFormula":"C27H30N2O","molecularWeight":398.5,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/155884822"}},"classification":{"family":"scra","familyLabel":"Synthetic cannabinoid (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (pharmaceutical research → illicit market)","summaryFr":"No known biosynthetic pathway: a synthetic molecule of the γ-carbolin-1-one class, with no known link to hemp or other plants.","originNote":"Fully synthetic molecule, with no known plant origin. It was identified in a herbal blend in which it was the main active ingredient. Its γ-carbolinone nucleus places it in the same chemical family as CUMYL-PEGACLONE (Haschimi et al., 2021).","discovered":""},"pharmacology":{"summaryFr":"CUMYL-CH-MEGACLONE is a synthetic agonist of the cannabinoid receptors, of the γ-carbolin-1-one family, and the cyclohexylmethyl analogue of CUMYL-PEGACLONE. Haschimi et al. (2021) measure at hCB1 a Ki of 1.01 nM, an affinity about 2.5 times higher than that of JWH-018, and an EC50 of 1.22 nM, with high efficacy (Emax of 143.4% above the receptor's constitutive activity). The authors suggest that it more closely resembles CUMYL-PEGACLONE pharmacologically. First identified in Hungary in December 2018 in a herbal blend, it was later found in samples from intoxicated patients. The file remains thin: no clinical study and no assessment of abuse potential in humans was found in the sources consulted, pharmacokinetics is documented only through a few blood samples, and the molecule is not listed in the INCB 2026 Green List, although it is scheduled as a narcotic in France.","receptorSummaryFr":"A high-efficacy agonist at CB1 receptors. Haschimi et al. (2021) measure at hCB1 a competitive binding affinity of Ki 1.01 nM, about 2.5 times higher than that of JWH-018, and an EC50 of 1.22 nM with an Emax of 143.4% above the receptor's constitutive activity, i.e. 1.13 times that of JWH-018. The authors suggest that its profile more closely resembles that of CUMYL-PEGACLONE, which the same study describes as a full agonist at hCB1. No CB2 affinity constant is reported in the sources consulted, and the abstracts consulted report no measurement at other targets.","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":95,"reported":"Ki 1,01 nM (Haschimi et coll., 2021) ; EC50 1,22 nM, Emax 143,4 % au-dessus de l'activité constitutive (hCB1)","confidence":"medium"}],"references":[{"label":"Haschimi et coll., Cumyl-CH-MEGACLONE : métabolisme de phase I humain et caractérisation pharmacologique, J Anal Toxicol, 2021","pmid":"32514544","doi":"10.1093/jat/bkaa065","url":"https://pubmed.ncbi.nlm.nih.gov/32514544/"},{"label":"Institóris et coll., Symptômes cliniques et concentrations sanguines de NPS chez des patients intoxiqués, région de Budapest (2018-2019), Clin Toxicol, 2022","pmid":"34080493","doi":"10.1080/15563650.2021.1928162","url":"https://pubmed.ncbi.nlm.nih.gov/34080493/"},{"label":"ANSM, Décision du 22 mai 2024 portant modification de la liste des substances classées comme stupéfiants","pmid":null,"doi":null,"url":"https://ansm.sante.fr/actualites/decision-du-22-05-2024-portant-modification-de-la-liste-des-substances-classees-comme-stupefiants"},{"label":"ANSM, Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (annexe IV)","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"OICS, Liste verte des substances psychotropes sous contrôle international, édition 2026","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CUMYL-CH-MEGACLONE, CID 155884822","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/155884822"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":12},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":5},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":12},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":20},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":18}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"controlled-named","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonised European Union control measure has been found for this molecule in the sources consulted, and it does not appear in the INCB 2026 Green List, which reproduces the schedules of the 1971 Convention.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"In France, this substance is scheduled as a narcotic by name. The ANSM decision of 22 May 2024, published on 24 May 2024, added “CUMYL-CH-MEGACLONE ou SGT-270” to annex IV of the decree of 22 February 1990, under the heading “Les cannabinoïdes suivants”. It is therefore not a mere attachment to a generic clause: the name appears on the consolidated list published by ANSM. Possession, transfer and use fall under the criminal regime for narcotics.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Haschimi et coll., Cumyl-CH-MEGACLONE : métabolisme de phase I humain et caractérisation pharmacologique, J Anal Toxicol, 2021","pmid":"32514544","doi":"10.1093/jat/bkaa065","url":"https://pubmed.ncbi.nlm.nih.gov/32514544/"},{"label":"Institóris et coll., Symptômes cliniques et concentrations sanguines de NPS chez des patients intoxiqués, région de Budapest (2018-2019), Clin Toxicol, 2022","pmid":"34080493","doi":"10.1080/15563650.2021.1928162","url":"https://pubmed.ncbi.nlm.nih.gov/34080493/"},{"label":"ANSM, Décision du 22 mai 2024 portant modification de la liste des substances classées comme stupéfiants","pmid":null,"doi":null,"url":"https://ansm.sante.fr/actualites/decision-du-22-05-2024-portant-modification-de-la-liste-des-substances-classees-comme-stupefiants"},{"label":"ANSM, Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (annexe IV)","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"OICS, Liste verte des substances psychotropes sous contrôle international, édition 2026","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CUMYL-CH-MEGACLONE, CID 155884822","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/155884822"}],"meta":{"slug":"cumyl-ch-megaclone","url":"https://en.phytogrammes.com/wiki/cumyl-ch-megaclone","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}