{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"BANLFAZSVPLZEB-UHFFFAOYSA-N","prefName":"CUMYL-NBMICA","symbol":"CUMYL-NBMICA","iupacName":"1-(2-bicyclo[2.2.1]heptanylmethyl)-N-(2-phenylpropan-2-yl)indole-3-carboxamide","aliases":["VH7ZT48Y4P"],"cas":null,"pubchemCid":"168319301","chebiId":null,"smiles":"CC(C)(C1=CC=CC=C1)NC(=O)C2=CN(C3=CC=CC=C32)CC4CC5CCC4C5","molecularFormula":"C26H30N2O","molecularWeight":386.5,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/168319301"}},"classification":{"family":"scra","familyLabel":"Synthetic cannabinoid (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (pharmaceutical research → illicit market)","summaryFr":"No known biosynthetic pathway: a synthetic molecule belonging to the indole-3-carboxamide class.","originNote":"An entirely synthetic molecule, absent from cannabis and from any other plant. It belongs to the norbornylmethyl-side-chain SCRAs that reached the drug market between 2019 and 2021, a series described as having circumvented German legislation. This compound was seized as a pure powder, whereas two other members of the series were found mixed with plant products.","discovered":""},"pharmacology":{"summaryFr":"CUMYL-NBMICA is a synthetic indole-3-carboxamide and a full CB1 receptor agonist according to Pulver et al. (2023). It belongs to three norbornylmethyl SCRAs whose Ki values lie between 0.25 and 1.87 nM, although the published abstract does not give the value specific to this compound. Described in 2021 from seizures, including a pure powder, it has no clinical or toxicological study in humans. The sources consulted come from in vitro pharmacology and forensic analysis, and the question of its French legal status remains open.","receptorSummaryFr":"Full agonist of the CB1 receptor. Pulver et al. (2023) study six SCRAs with cyclobutylmethyl or norbornylmethyl side chains, all full CB1 agonists when compared with Δ9-THC and CP-55,940. This compound is one of the three norbornylmethyl SCRAs in that study, for which the published abstract reports a Ki between 0.25 and 1.87 nM and functional EC50 values between 1.78 and 169 nM. The abstract does not give the value specific to this compound. According to the authors, the bulk of the norbornylmethyl side chain increases the affinity and activity of almost all core structures tested. No data on the CB2 receptor were found in the sources consulted.","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":91,"reported":"Ki compris entre 0,25 et 1,87 nM pour les trois SCRA à chaîne norbornylméthyle (Pulver et coll., 2023) ; valeur propre à ce composé non donnée dans le résumé publié","confidence":"medium"}],"references":[{"label":"Pulver et coll., pharmacologie, prévalence en Allemagne et données analytiques des agonistes à chaînes cyclobutylméthyle et norbornylméthyle, Drug Test Anal, 2023","pmid":"36541839","doi":"10.1002/dta.3427","url":"https://pubmed.ncbi.nlm.nih.gov/36541839/"},{"label":"Pulver et coll., jeu de données d'identification de trois SCRA à chaîne norbornylméthyle, Data in Brief, 2021","pmid":"34988267","doi":"10.1016/j.dib.2021.107628","url":"https://pubmed.ncbi.nlm.nih.gov/34988267/"},{"label":"Giorgetti et coll., métabolisme de phase I chez l'humain du Cumyl-CBMEGACLONE, du Cumyl-NBMEGACLONE et du Cumyl-NBMINACA, Drug Test Anal, 2025","pmid":"39218806","doi":"10.1002/dta.3791","url":"https://pubmed.ncbi.nlm.nih.gov/39218806/"},{"label":"ANSM, Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Liste verte 2026 (tableaux de la Convention de 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CUMYL-NBMICA, CID 168319301","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/168319301"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":10},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":5},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":10},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":15},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":15}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"evolving","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonised control measure at European Union level was identified in the sources consulted: control falls to Member States. In Germany, the 2020 revision of the new psychoactive substances act scheduled the cyclobutylmethyl SCRAs, while the norbornylmethyl derivatives, of which this compound is one, were detected after that revision.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"In France, this compound is not named on the consolidated list of narcotics updated on 16 February 2026 by ANSM. Whether it falls under the generic definition of 3-carboxamide indoles in annex IV of the amended order of 22 February 1990 is not established with certainty: the amide condition is met, since the amide nitrogen carries a cumyl group, but the definition lists bicyclo[2.2.1]heptanyl only among the substituents of the amide nitrogen, not among those of the indole nitrogen, where it retains cycloalkylmethyl without mentioning bicyclic groups. The French status therefore remains uncertain until an ANSM decision names this compound.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Pulver et coll., pharmacologie, prévalence en Allemagne et données analytiques des agonistes à chaînes cyclobutylméthyle et norbornylméthyle, Drug Test Anal, 2023","pmid":"36541839","doi":"10.1002/dta.3427","url":"https://pubmed.ncbi.nlm.nih.gov/36541839/"},{"label":"Pulver et coll., jeu de données d'identification de trois SCRA à chaîne norbornylméthyle, Data in Brief, 2021","pmid":"34988267","doi":"10.1016/j.dib.2021.107628","url":"https://pubmed.ncbi.nlm.nih.gov/34988267/"},{"label":"Giorgetti et coll., métabolisme de phase I chez l'humain du Cumyl-CBMEGACLONE, du Cumyl-NBMEGACLONE et du Cumyl-NBMINACA, Drug Test Anal, 2025","pmid":"39218806","doi":"10.1002/dta.3791","url":"https://pubmed.ncbi.nlm.nih.gov/39218806/"},{"label":"ANSM, Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Liste verte 2026 (tableaux de la Convention de 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CUMYL-NBMICA, CID 168319301","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/168319301"}],"meta":{"slug":"cumyl-nbmica","url":"https://en.phytogrammes.com/wiki/cumyl-nbmica","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}