{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"XYSIFMHZXZATQO-UHFFFAOYSA-N","prefName":"FDU-NNE1","symbol":"FDU-NNE1","iupacName":"1-[(4-fluorophenyl)methyl]-N-naphthalen-1-ylindole-3-carboxamide","aliases":[],"cas":null,"pubchemCid":"122213806","chebiId":null,"smiles":"C1=CC=C2C(=C1)C=CC=C2NC(=O)C3=CN(C4=CC=CC=C43)CC5=CC=C(C=C5)F","molecularFormula":"C26H19FN2O","molecularWeight":394.4,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/122213806"}},"classification":{"family":"scra","familyLabel":"Synthetic cannabinoid (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (pharmaceutical research → illicit market)","summaryFr":"No biosynthetic pathway: the molecule is obtained by chemical synthesis and belongs to the class of N-naphthyl indole-3-carboxamides.","originNote":"A synthetic molecule that its first identifiers describe as a new compound. It was found in 2014 in products sold in Japan, where it was detected at the same time as FDU-PB-22, an ester carrying the same fluorobenzylindole fragment.","discovered":""},"pharmacology":{"summaryFr":"FDU-NNE1 is a synthetic indole-3-carboxamide: an indole ring carries a 4-fluorobenzyl group on its nitrogen, and its carboxamide function is linked to a naphthyl group. Uchiyama and colleagues described it in 2015, after finding it in 2014 in illicit products bought in Japan, where it was detected together with FDU-PB-22. The authors named the compound from its two fragments: the indolic carbonyl of FDU-PB-22 and the naphthylamino group of NNEI. No affinity constant for the CB1 or CB2 receptors is published, and no data on its effects in humans was found. In France, it is a narcotic under the generic clause for 3-carboxamide indole derivatives, not by its name.","receptorSummaryFr":"This publication does not assess any receptor activity. Its authors present the compound as a synthetic cannabinoid and compare its structure with those of FDU-PB-22 and NNEI. No affinity constant for CB1 or CB2 is published in the sources consulted, and its mode of action at these receptors is not documented.","binding":[{"target":"CB1","efficacy":"modulator","relativeActivity":5,"reported":"aucune constante d'affinité publiée ; type d'action sur CB1 non documenté","confidence":"medium"},{"target":"CB2","efficacy":"modulator","relativeActivity":5,"reported":"aucune constante d'affinité publiée ; type d'action sur CB2 non documenté","confidence":"medium"}],"references":[{"label":"Uchiyama et coll., FDU-NNE1 dans des produits illicites au Japon, Forensic Toxicol 2015","pmid":"26257833","doi":"10.1007/s11419-015-0268-7","url":"https://pubmed.ncbi.nlm.nih.gov/26257833/"},{"label":"PubChem, CID 122213806 : formule, masse moléculaire et InChIKey","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/122213806"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants (mise à jour du 16 février 2026), annexe IV","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Green List 2026 (substances placées sous contrôle international)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":3},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":3},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":3},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":3},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":3}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"controlled-clause","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonised control measure at the level of the European Union was found in the sources consulted for this compound. Control therefore rests with the national legislation of the Member States.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"A narcotic under a generic clause, not by its name. The consolidated list of narcotics (updated 16 February 2026) does not name this compound. It names « NNE1 » (NNEI), with a pentyl chain, not this fluorobenzyl variant. The compound does fall under the family « 3-carboxamide indole derivatives » in Annex IV of the decree of 22 February 1990, whose conditions are all met: the indole nitrogen carries a halobenzyl group (here 4-fluorobenzyl), the definition allows the indole ring to be substituted or not (here it is not), and the carboxamide nitrogen carries a naphthyl group.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Uchiyama et coll., FDU-NNE1 dans des produits illicites au Japon, Forensic Toxicol 2015","pmid":"26257833","doi":"10.1007/s11419-015-0268-7","url":"https://pubmed.ncbi.nlm.nih.gov/26257833/"},{"label":"PubChem, CID 122213806 : formule, masse moléculaire et InChIKey","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/122213806"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants (mise à jour du 16 février 2026), annexe IV","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Green List 2026 (substances placées sous contrôle international)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"}],"meta":{"slug":"fdu-nne1","url":"https://en.phytogrammes.com/wiki/fdu-nne1","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}