{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"UXOFEILQVZFLRH-UHFFFAOYSA-N","prefName":"FUB-144","symbol":"FUB-144","iupacName":"[1-[(4-fluorophenyl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone","aliases":["FUB-UR-144"],"cas":"2185863-15-2","pubchemCid":"118796439","chebiId":null,"smiles":"CC1(C(C1(C)C)C(=O)C2=CN(C3=CC=CC=C32)CC4=CC=C(C=C4)F)C","molecularFormula":"C23H24FNO","molecularWeight":349.4,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/118796439"}},"classification":{"family":"scra","familyLabel":"Synthetic cannabinoid (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (pharmaceutical research → illicit market)","summaryFr":"No biosynthetic pathway: synthetic compound of the tetramethylcyclopropanoylindole class.","originNote":"Synthetic compound with no plant or animal origin. It was identified in seizures: two samples seized in Kuwait between 2019 and 2023 were identified as FUB-144 by NMR (Al-Matrouk and Orabi, 2025). Hess et al. (2016) studied it among synthetic cannabinoids identified as constituents of spice blends.","discovered":""},"pharmacology":{"summaryFr":"FUB-144, also called FUB-UR-144, is a synthetic cannabinoid of the tetramethylcyclopropanoylindole family, with the systematic name [1-[(4-fluorophenyl)methyl]indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone. On recombinant human receptors it binds CB1 with a Ki of 27.2 nM and CB2 with a Ki of 1.19 nM, meaning higher affinity for CB2 (Marusich et al., 2022). It has been studied as a constituent of herbal incense blends known as spice (Hess et al., 2016) and identified in seizures (Al-Matrouk and Orabi, 2025). No human pharmacokinetic or toxicological data are published. In France it is not named in the list of narcotics but falls under a generic clause, the 'Indol-3-yl methanone' definition.","receptorSummaryFr":"FUB-144 is an agonist of CB1 and CB2 receptors. On recombinant human receptors it binds CB1 with a Ki of 27.2 nM and CB2 with a Ki of 1.19 nM (Marusich et al., 2022). In the GTPγS assay of the same study it activates both receptors, with an EC50 of 90.6 nM at CB1 and 4.61 nM at CB2. Hess et al. (2016) report nearly identical affinity at both receptors for the pair XLR-11 and FUB-144.","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":76,"reported":"Ki 27,2 nM ; EC50 90,6 nM en GTPγS (Marusich et coll., 2022, récepteur humain recombinant)","confidence":"medium"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":90,"reported":"Ki 1,19 nM ; EC50 4,61 nM en GTPγS (Marusich et coll., 2022, récepteur humain recombinant)","confidence":"medium"}],"references":[{"label":"Marusich et coll., Pharmacologie in vitro et in vivo de neuf agonistes synthétiques des récepteurs cannabinoïdes, Pharmacol Biochem Behav 2022","pmid":"36154844","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/36154844/"},{"label":"Hess et coll., Évaluation pharmacologique de cannabinoïdes de synthèse identifiés comme constituants de spice, Forensic Toxicol 2016","pmid":"27429655","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/27429655/"},{"label":"Kim et coll., Métabolisme in vitro et in vivo du FUB-144 par UHPLC-HRMS, Arch Toxicol 2026","pmid":"41807793","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41807793/"},{"label":"Shetty et coll., Pharmacologie comportementale de cannabinoïdes de synthèse indazole, indole et benzimidazole, J Cannabis Res 2026","pmid":"41526973","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41526973/"},{"label":"Al-Matrouk et Orabi, Identification de cannabinoïdes de synthèse saisis au Koweït (2019-2023) par RMN, Forensic Sci Res 2025","pmid":"40302876","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/40302876/"},{"label":"ANSM, Liste consolidée des substances classées comme stupéfiants (mise à jour du 16 février 2026)","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Green List 2026 (substances des conventions de 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CID 118796439 (FUB-144)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/118796439"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":5},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":3},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":5},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":3},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":5}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"controlled-clause","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonised European Union control measure is documented for this compound in the sources consulted.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"FUB-144 is not named in the consolidated French list of narcotics (updated 16 February 2026). It does fall under the generic definition 'Indol-3-yl methanone' (Annex IV, page 41 of the PDF): the indole nitrogen carries a halobenzyl substituent (here a 4-fluorobenzyl) and the methanone carbon carries a cyclopropyl group, substituted or not (here a 2,2,3,3-tetramethylcyclopropyl). Both conditions are met, so the compound is covered by this clause.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Marusich et coll., Pharmacologie in vitro et in vivo de neuf agonistes synthétiques des récepteurs cannabinoïdes, Pharmacol Biochem Behav 2022","pmid":"36154844","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/36154844/"},{"label":"Hess et coll., Évaluation pharmacologique de cannabinoïdes de synthèse identifiés comme constituants de spice, Forensic Toxicol 2016","pmid":"27429655","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/27429655/"},{"label":"Kim et coll., Métabolisme in vitro et in vivo du FUB-144 par UHPLC-HRMS, Arch Toxicol 2026","pmid":"41807793","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41807793/"},{"label":"Shetty et coll., Pharmacologie comportementale de cannabinoïdes de synthèse indazole, indole et benzimidazole, J Cannabis Res 2026","pmid":"41526973","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/41526973/"},{"label":"Al-Matrouk et Orabi, Identification de cannabinoïdes de synthèse saisis au Koweït (2019-2023) par RMN, Forensic Sci Res 2025","pmid":"40302876","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/40302876/"},{"label":"ANSM, Liste consolidée des substances classées comme stupéfiants (mise à jour du 16 février 2026)","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Green List 2026 (substances des conventions de 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CID 118796439 (FUB-144)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/118796439"}],"meta":{"slug":"fub-144","url":"https://en.phytogrammes.com/wiki/fub-144","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}