{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"VREQTLWJHFQLEX-UHFFFAOYSA-N","prefName":"FUB-JWH-018","symbol":"FUB-JWH-018","iupacName":"[1-[(4-fluorophenyl)methyl]indol-3-yl]-naphthalen-1-ylmethanone","aliases":["FUB-018","(1-(4-fluorobenzyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone"],"cas":null,"pubchemCid":"121489975","chebiId":null,"smiles":"C1=CC=C2C(=C1)C=CC=C2C(=O)C3=CN(C4=CC=CC=C43)CC5=CC=C(C=C5)F","molecularFormula":"C26H18FNO","molecularWeight":379.4,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/121489975"}},"classification":{"family":"scra","familyLabel":"Synthetic cannabinoid (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (pharmaceutical research → illicit market)","summaryFr":"No biosynthetic route: a synthetic molecule of the naphthoylindole family.","originNote":"A synthetic molecule; no natural occurrence is reported in the sources consulted. It appears in Belgian detection data for 2015 (Wille et al., 2018).","discovered":""},"pharmacology":{"summaryFr":"FUB-JWH-018, or (1-(4-fluorobenzyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone, is a synthetic cannabinoid of the naphthoylindole family, whose skeleton resembles that of JWH-018. It differs from it by a 4-fluorobenzyl group in place of the pentyl chain on the indole nitrogen. Schoeder et al. (2018) report Ki values of 3.27 ± 1.76 nM at CB1 and 1.34 ± 0.48 nM at CB2, and no EC50 or IC50 is reached up to 10 µM at GPR55 and GPR18. The compound was reported in samples from drivers tested in Belgium between January and August 2015 (Wille et al., 2018). It is classified as a narcotic in France, and the sources consulted publish no pharmacokinetic, metabolic or clinical data for it.","receptorSummaryFr":"Ligand of the CB1 and CB2 receptors with high nanomolar affinity according to Schoeder et al. (2018), who compare it with two naphthoyl-indazoles studied earlier, THJ-018 and THJ-2201. Table 1 of that paper reports a Ki of 3.27 ± 1.76 nM at CB1 and 1.34 ± 0.48 nM at CB2 (standard error). In the cAMP accumulation assay of the same study, almost all compounds tested behave as agonists with high efficacy, and FUB-JWH-018 is not cited among the exceptions. At GPR55 and GPR18, tested in beta-arrestin assays, no EC50 or IC50 is reached up to 10 µM, and the responses measured stay at 30% or below.","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":90,"reported":"Ki = 3,27 ± 1,76 nM (CB1 humain, cellules CHO ; erreur standard, Schoeder et coll., 2018, tableau 1)","confidence":"medium"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":95,"reported":"Ki = 1,34 ± 0,48 nM (CB2 humain, cellules CHO ; erreur standard, Schoeder et coll., 2018, tableau 1)","confidence":"medium"}],"references":[{"label":"Schoeder et coll., Évaluation pharmacologique de nouveaux constituants du « Spice » : cannabinoïdes de synthèse à squelettes indole, indazole, benzimidazole et carbazole, Forensic Toxicology, 2018","pmid":"29963207","doi":"10.1007/s11419-018-0415-z","url":"https://pubmed.ncbi.nlm.nih.gov/29963207/"},{"label":"Wille et coll., Prévalence des nouvelles substances psychoactives et des médicaments chez les conducteurs sous influence de drogues en Belgique, Drug Testing and Analysis, 2018","pmid":"28640970","doi":"10.1002/dta.2232","url":"https://pubmed.ncbi.nlm.nih.gov/28640970/"},{"label":"ANSM, Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (annexe IV, famille des indol-3-yl méthanones)","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Liste verte 2026 (tableaux des conventions de 1961 et 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CID 121489975 (FUB-JWH-018)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/121489975"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":5},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":5},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":5},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":5},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":10}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"controlled-named","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonised control measure at European Union level is cited for this compound in the sources consulted, so control rests with national legislation. It is also absent from the INCB Green List 2026, which reproduces the schedules of the 1961 and 1971 conventions.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"A substance classified as a narcotic in France and named explicitly. It appears in the consolidated list of substances classified as narcotics, updated on 16 February 2026, in annex IV (substances classified in France or the European Union but not classified under the international conventions), within the indol-3-yl methanone family: « FUB-JWH-018 ou (1-(4-fluorobenzyl)-1H-indol-3-yl) (naphtalen-1-yl) méthanone ». Its structure also meets the generic definition of that family: a halobenzyl substituent on the indole nitrogen and a naphthyl group on the methanone carbon. Its classification places it under the narcotics regime.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Schoeder et coll., Évaluation pharmacologique de nouveaux constituants du « Spice » : cannabinoïdes de synthèse à squelettes indole, indazole, benzimidazole et carbazole, Forensic Toxicology, 2018","pmid":"29963207","doi":"10.1007/s11419-018-0415-z","url":"https://pubmed.ncbi.nlm.nih.gov/29963207/"},{"label":"Wille et coll., Prévalence des nouvelles substances psychoactives et des médicaments chez les conducteurs sous influence de drogues en Belgique, Drug Testing and Analysis, 2018","pmid":"28640970","doi":"10.1002/dta.2232","url":"https://pubmed.ncbi.nlm.nih.gov/28640970/"},{"label":"ANSM, Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (annexe IV, famille des indol-3-yl méthanones)","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Liste verte 2026 (tableaux des conventions de 1961 et 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, CID 121489975 (FUB-JWH-018)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/121489975"}],"meta":{"slug":"fub-jwh-018","url":"https://en.phytogrammes.com/wiki/fub-jwh-018","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}