{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"KUESSZMROAFKQJ-UHFFFAOYSA-N","prefName":"FUBIMINA","symbol":"FUBIMINA","iupacName":"[1-(5-fluoropentyl)benzimidazol-2-yl]-naphthalen-1-ylmethanone","aliases":["FUBIMINA","BIM-2201","BZ-2201","FTHJ","(1-(5-Fluoropentyl)benzimidazol-2-yl)-(1-naphthyl)methanone"],"cas":null,"pubchemCid":"124519316","chebiId":null,"smiles":"C1=CC=C2C(=C1)C=CC=C2C(=O)C3=NC4=CC=CC=C4N3CCCCCF","molecularFormula":"C23H21FN2O","molecularWeight":360.4,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/124519316"}},"classification":{"family":"scra","familyLabel":"Synthetic cannabinoid (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (pharmaceutical research → illicit market)","summaryFr":"No biosynthetic pathway: FUBIMINA does not derive from hemp. It is a synthetic cannabinoid, obtained by laboratory chemistry, of the acylated benzimidazole class, unrelated to the terpenophenols of the plant.","originNote":"Entirely synthetic molecule. It was first detected in 2013 in herbal-type products bought online, according to Diao et al. (2016), who cite Uchiyama et al. It is easily accessible online and is designated by several names: FUBIMINA, BIM-2201, BZ-2201 and FTHJ. Scheduled in Japan since August 2014 (Diao et al., 2016), it is the isomer of THJ-2201, from which it is distinguished by mass spectrometry.","discovered":"2013"},"pharmacology":{"summaryFr":"FUBIMINA, also designated BIM-2201, is a synthetic cannabinoid of the benzimidazole class, a fluoro derivative of BIM-018 and an isomer of THJ-2201. Schoeder et al. (2018) measure an affinity of 502 nM at CB1 and of 99.0 nM at CB2. Wiley et al. (2015) describe it as a full agonist in the [35S]GTPγS assay and report, in mice, reduced locomotor activity, antinociception, hypothermia and catalepsy. Schoeder et al. observe only a partial activation of both receptors at 10 µM. First detected in 2013, it is expressly listed among the narcotics in France. No human data are published in the sources consulted.","receptorSummaryFr":"Ligand of the CB1 and CB2 receptors. Schoeder et al. (2018) measure, using radioligand binding assays, an affinity of 502 nM at CB1 and of 99.0 nM at CB2. Wiley et al. (2015) describe binding and activation of both receptors, with full efficacy in the [35S]GTPγS binding assay, where THC is a partial agonist. Schoeder et al., by contrast, measure only a partial activation of both receptors at 10 µM, comparable to that of THC, in a cyclic AMP accumulation assay. The affinities reported by Wiley et al. are higher, at 296 nM at CB1 and 23.5 nM at CB2, according to Schoeder et al., who cite them.","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":50,"reported":"Ki 502 nM (Schoeder et coll., 2018)","confidence":"medium"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":65,"reported":"Ki 99,0 nM (Schoeder et coll., 2018)","confidence":"medium"}],"references":[{"label":"Wiley et coll., AB-CHMINACA, AB-PINACA et FUBIMINA chez la souris : affinité et puissance, J Pharmacol Exp Ther 2015","pmid":"26105953","doi":"10.1124/jpet.115.225326","url":"https://pubmed.ncbi.nlm.nih.gov/26105953/"},{"label":"Diao et coll., distinguer la FUBIMINA de son isomère THJ-2201 : métabolisme dans les hépatocytes humains, Forensic Toxicol 2016","pmid":"27547265","doi":"10.1007/s11419-016-0312-2","url":"https://pubmed.ncbi.nlm.nih.gov/27547265/"},{"label":"Schoeder et coll., nouveaux constituants du « Spice » : évaluation pharmacologique des cannabinoïdes de synthèse indole, indazole, benzimidazole et carbazole, Forensic Toxicol 2018","pmid":"29963207","doi":"10.1007/s11419-018-0415-z","url":"https://pubmed.ncbi.nlm.nih.gov/29963207/"},{"label":"ANSM · Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026, annexe IV","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"Légifrance · Arrêté du 3 octobre 2017 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants","pmid":null,"doi":null,"url":"https://www.legifrance.gouv.fr/jorf/id/JORFTEXT000035754758"},{"label":"OICS · Liste verte des substances psychotropes sous contrôle international, édition 2026 (FUBIMINA non inscrite)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem · CID 124519316, FUBIMINA","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/124519316"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":8},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":5},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":15},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":10},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":20}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"controlled-named","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonised European Union control measure was found in the sources consulted for this record: control falls under the national legislation of the Member States.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Narcotic in France. FUBIMINA is expressly listed in annex IV of the consolidated list of narcotics (updated 16 February 2026), in the block of the following cannabinoids, together with their isomers, stereoisomers, esters, ethers and salts. This listing stems from the order of 3 October 2017 amending the order of 22 February 1990.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Wiley et coll., AB-CHMINACA, AB-PINACA et FUBIMINA chez la souris : affinité et puissance, J Pharmacol Exp Ther 2015","pmid":"26105953","doi":"10.1124/jpet.115.225326","url":"https://pubmed.ncbi.nlm.nih.gov/26105953/"},{"label":"Diao et coll., distinguer la FUBIMINA de son isomère THJ-2201 : métabolisme dans les hépatocytes humains, Forensic Toxicol 2016","pmid":"27547265","doi":"10.1007/s11419-016-0312-2","url":"https://pubmed.ncbi.nlm.nih.gov/27547265/"},{"label":"Schoeder et coll., nouveaux constituants du « Spice » : évaluation pharmacologique des cannabinoïdes de synthèse indole, indazole, benzimidazole et carbazole, Forensic Toxicol 2018","pmid":"29963207","doi":"10.1007/s11419-018-0415-z","url":"https://pubmed.ncbi.nlm.nih.gov/29963207/"},{"label":"ANSM · Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026, annexe IV","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"Légifrance · Arrêté du 3 octobre 2017 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants","pmid":null,"doi":null,"url":"https://www.legifrance.gouv.fr/jorf/id/JORFTEXT000035754758"},{"label":"OICS · Liste verte des substances psychotropes sous contrôle international, édition 2026 (FUBIMINA non inscrite)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem · CID 124519316, FUBIMINA","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/124519316"}],"meta":{"slug":"fubimina","url":"https://en.phytogrammes.com/wiki/fubimina","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}