{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"VPBJQDBKZSHCPC-UHFFFAOYSA-N","prefName":"JWH-030","symbol":"JWH-030","iupacName":"naphthalen-1-yl-(1-pentylpyrrol-3-yl)methanone","aliases":["Naphthalen-1-yl(1-pentyl-1H-pyrrol-3-yl)methanone","1-naphthalenyl(1-pentyl-1h-pyrrol-3-yl)methanone","Naphthalen-1-yl-(1-pentylpyrrol-3-yl)methanone"],"cas":"162934-73-8","pubchemCid":"9971539","chebiId":null,"smiles":"CCCCCN1C=CC(=C1)C(=O)C2=CC=CC3=CC=CC=C32","molecularFormula":"C20H21NO","molecularWeight":291.4,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/9971539"}},"classification":{"family":"scra","familyLabel":"Synthetic cannabinoid (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (pharmaceutical research → illicit market)","summaryFr":"No biosynthetic pathway: JWH-030 is produced by no living organism and belongs to no hemp chemotype. It belongs to synthetic chemistry alone: a pyrrole carries on its nitrogen a pentyl chain and, at position 3, a carbonyl group linking it to a naphthalene ring.","originNote":"Synthetic molecule, described as such in the sources consulted. It has been detected in illicit products in Japan, where it is one of a dozen synthetic cannabinoids reported as newly distributed designer drugs (Uchiyama et al., 2013).","discovered":""},"pharmacology":{"summaryFr":"JWH-030, or naphthalen-1-yl-(1-pentylpyrrol-3-yl)methanone, is a synthetic cannabinoid of the JWH series belonging to the naphthoylpyrroles. It is the pyrrole analogue of JWH-018, whose indole ring is replaced by a pyrrole. On the mouse vas deferens, it inhibits electrically evoked contractions with an IC50 of 3.38 nM, placing it close to JWH-007 (2.56 nM), and its effect is antagonized by SR141716A (Pertwee et al., 1995). The available safety data remain preliminary: it prolongs the QT interval in rats and blocks the hERG channel with an IC50 of 88.36 µM (Yun et al., 2016). No clinical human data are published in the sources consulted.","receptorSummaryFr":"Functional agonist at CB1 receptors. On the mouse vas deferens, it inhibits electrically evoked contractions with an IC50 of 3.38 nM, a value comparable to that of JWH-007 (2.56 nM) and lower than that of 1-heptyl-3-(1-naphthoyl)indole (639 nM). Its effect is antagonized by SR141716A, a selective CB1 antagonist, with an apparent Kd of 3.86 nM in this tissue (Pertwee et al., 1995). No CB2 affinity constant is verified in the sources consulted. In a cell model, its cytotoxicity is inhibited by the CB2 antagonist AM630 but not by rimonabant (Yun et al., 2016).","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":88,"reported":"CI50 3,38 nM sur le déférent de souris (Pertwee et coll., 1995) ; valeur fonctionnelle, aucune constante Ki vérifiée dans les sources consultées","confidence":"medium"}],"references":[{"label":"Pertwee et coll., trois agonistes cannabinoïdes nouveaux sur le déférent de souris, Eur J Pharmacol 1995","pmid":"8666005","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/8666005/"},{"label":"Yun et coll., JWH-030 et allongement de l'intervalle QT par blocage du canal hERG, Toxicol Res 2016","pmid":"30090465","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/30090465/"},{"label":"Tampus et coll., potentiel d'abus de JWH-030, JWH-175 et JWH-176 chez le rongeur, Biomol Ther 2015","pmid":"26535085","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/26535085/"},{"label":"Uchiyama et coll., cannabinoïdes de synthèse détectés dans des produits illicites, Forensic Sci Int 2013","pmid":"23063179","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/23063179/"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Liste verte 2026 (substances psychotropes, convention de 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, composé CID 9971539 (JWH-030)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/9971539"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":5},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":5},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":10},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":15},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":10}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"controlled-named","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonized control measure at European Union level is documented for this molecule in the sources consulted: control therefore rests with the member states. The INCB Green List 2026, which lists the psychotropic substances of the 1971 Convention, does not mention JWH-030.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"A substance classified as a narcotic in France and named explicitly. JWH-030 appears in annex IV of the consolidated list of narcotics (ANSM, updated 16 February 2026, based on the amended order of 22 February 1990), in the naphthoylpyrrole block, where it is named among the examples. The generic definition of that family (pyrrole nitrogen carrying an alkyl group, carbonyl linked at position 3 to a naphthyl) also covers its structure.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Pertwee et coll., trois agonistes cannabinoïdes nouveaux sur le déférent de souris, Eur J Pharmacol 1995","pmid":"8666005","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/8666005/"},{"label":"Yun et coll., JWH-030 et allongement de l'intervalle QT par blocage du canal hERG, Toxicol Res 2016","pmid":"30090465","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/30090465/"},{"label":"Tampus et coll., potentiel d'abus de JWH-030, JWH-175 et JWH-176 chez le rongeur, Biomol Ther 2015","pmid":"26535085","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/26535085/"},{"label":"Uchiyama et coll., cannabinoïdes de synthèse détectés dans des produits illicites, Forensic Sci Int 2013","pmid":"23063179","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/23063179/"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"},{"label":"INCB, Liste verte 2026 (substances psychotropes, convention de 1971)","pmid":null,"doi":null,"url":"https://www.incb.org/incb/uploads/documents/Psychotropics/forms/greenlist/2026/2510307E.pdf"},{"label":"PubChem, composé CID 9971539 (JWH-030)","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/9971539"}],"meta":{"slug":"jwh-030","url":"https://en.phytogrammes.com/wiki/jwh-030","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}