{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"ANVCANCAZRKUGF-UHFFFAOYSA-N","prefName":"JWH-032","symbol":"JWH-032","iupacName":"naphthalen-1-yl-(1-propylpyrrol-3-yl)methanone","aliases":["JWH-032","1-Naphthyl(1-propyl-1H-pyrrol-3-yl)methanone"],"cas":null,"pubchemCid":"10084127","chebiId":null,"smiles":"CCCN1C=CC(=C1)C(=O)C2=CC=CC3=CC=CC=C32","molecularFormula":"C18H17NO","molecularWeight":263.3,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/10084127"}},"classification":{"family":"scra","familyLabel":"Synthetic cannabinoid (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origin (pharmaceutical research → illicit market)","summaryFr":"No known biosynthetic pathway: a synthetic organic molecule from the acylpyrrole chemical family. No manufacturing process is described here.","originNote":"Synthetic molecule, described as a research compound. No source consulted reports it as produced by a plant or another living organism.","discovered":""},"pharmacology":{"summaryFr":"JWH-032 is an N-propyl naphthoylpyrrole, a research compound from the program of John W. Huffman at Clemson University. It differs from JWH-030 by a chain two carbons shorter than the pentyl chain. In the 2014 review by Wiley et al., naphthoylpyrroles with an N-alkyl chain from methyl to propyl do not bind the CB1 receptor (Ki above 10 000 nM), whereas JWH-030 reaches a Ki of 87 nM. CB2 affinity and functional efficacy are not documented in the sources consulted, and no human data were found.","receptorSummaryFr":"No measurable binding to CB1 is reported up to 10 µM: Ki > 10 000 nM (Wiley et al., 2014; BindingDB database, rat CB1). In the 2014 review, naphthoylpyrroles with an N-alkyl chain from methyl to propyl do not bind CB1, whereas lengthening the chain to butyl or longer improved affinity, and the pentyl homologue JWH-030 reached a Ki of 87 nM. No CB2 affinity constant and no functional efficacy measurement were found in the sources consulted, so the action profile of JWH-032 remains uncharacterized.","binding":[{"target":"CB1","efficacy":"modulator","relativeActivity":5,"reported":"Ki > 10 000 nM (Wiley et coll., 2014 ; BindingDB, CB1 de rat)","confidence":"medium"}],"references":[{"label":"Wiley et coll., relations structure-activité et effets in vivo des cannabinoïdes de synthèse (revue), Life Sci 2014","pmid":"24071522","doi":"10.1016/j.lfs.2013.09.011","url":"https://pubmed.ncbi.nlm.nih.gov/24071522/"},{"label":"Wiley et coll., relations structure-activité des cannabinoïdes dérivés de l'indole et du pyrrole, J Pharmacol Exp Ther 1998","pmid":"9618400","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/9618400/"},{"label":"Pertwee et coll., caractérisation de trois agonistes cannabinoïdes nouveaux sur le canal déférent de souris (dont la 1-pentyl-3-(1-naphtoyl)pyrrole), Eur J Pharmacol 1995","pmid":"8666005","doi":"10.1016/0014-2999(95)00318-f","url":"https://pubmed.ncbi.nlm.nih.gov/8666005/"},{"label":"BindingDB, entrée BDBM85802 (JWH-032), Ki sur le CB1 de rat, données du programme PDSP","pmid":null,"doi":null,"url":"https://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85802"},{"label":"PubChem, CID 10084127 (JWH-032), identifiants et synonymes","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/10084127"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (annexe IV, famille des naphtoylpyrroles)","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Calm","description":"Relaxation of body and mind; reduced mental noise without marked drowsiness.","intensity":5},{"key":"focus","label":"Clarity","description":"Sustained attention and clear thinking; functional lucidity, not euphoria.","intensity":5},{"key":"sleep","label":"Sleep","description":"Sedative effect: aids sleep onset and the continuity of deep sleep.","intensity":5},{"key":"appetite","label":"Appetite","description":"Stimulation of hunger and of taste appreciation (the “munchies” effect).","intensity":5},{"key":"uplift","label":"High","description":"Euphoria and sensory intensity; altered perception of time and space.","intensity":5}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"unscheduled","scheduleLabel":"Unscheduled","frScheduleStatus":"controlled-clause","tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":null,"reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"No harmonised European Union control measure was found in the sources consulted for this compound; control currently rests with national legislation.","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Classed as a narcotic in France by a family clause, not by name: JWH-032 is not named in the ANSM consolidated list of 16 February 2026. It meets the conditions of the naphthoylpyrroles definition in Annex IV of the order of 22 February 1990, block \"Ainsi que toute molécule appartenant à la famille des\": a pyrrol-3-yl (1-naphthyl) methanone core, an alkyl substituent on the pyrrole nitrogen (here propyl), with the pyrrole and naphthyl rings substituted or not (here, they are not).","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Wiley et coll., relations structure-activité et effets in vivo des cannabinoïdes de synthèse (revue), Life Sci 2014","pmid":"24071522","doi":"10.1016/j.lfs.2013.09.011","url":"https://pubmed.ncbi.nlm.nih.gov/24071522/"},{"label":"Wiley et coll., relations structure-activité des cannabinoïdes dérivés de l'indole et du pyrrole, J Pharmacol Exp Ther 1998","pmid":"9618400","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/9618400/"},{"label":"Pertwee et coll., caractérisation de trois agonistes cannabinoïdes nouveaux sur le canal déférent de souris (dont la 1-pentyl-3-(1-naphtoyl)pyrrole), Eur J Pharmacol 1995","pmid":"8666005","doi":"10.1016/0014-2999(95)00318-f","url":"https://pubmed.ncbi.nlm.nih.gov/8666005/"},{"label":"BindingDB, entrée BDBM85802 (JWH-032), Ki sur le CB1 de rat, données du programme PDSP","pmid":null,"doi":null,"url":"https://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85802"},{"label":"PubChem, CID 10084127 (JWH-032), identifiants et synonymes","pmid":null,"doi":null,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/10084127"},{"label":"ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (annexe IV, famille des naphtoylpyrroles)","pmid":null,"doi":null,"url":"https://ansm.sante.fr/uploads/2026/02/17/20260217-stupefiants-liste-consolidee.pdf"}],"meta":{"slug":"jwh-032","url":"https://en.phytogrammes.com/wiki/jwh-032","lastVerified":"2026-05-01","dataUpdatedAt":"2026-10-13","confidence":"high","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}