Cannabinoid comparator
Two Canna·wiki molecules side by side: formula, origin, receptors and legal status, straight from the encyclopedia records.
CBD
Cannabidiol
Δ9-THC
Δ⁹-Tetrahydrocannabinol
Molecular formula
C₂₁H₃₀O₂
C₂₁H₃₀O₂
Identification
1940
1964
Origin
Plant
Plant
Receptors
Negative allosteric modulator of CB1 (Ki > 10 µM), 5-HT1A agonist (Ki ≈ 16 µM), TRPV1 agonist (EC50 ≈ 3.5 µM), GPR55 antagonist
Partial CB1 agonist (Ki ≈ 40 nM), partial CB2 agonist (Ki ≈ 36 nM)
Status in France
Permitted · adult use
Narcotic · threshold 0.30% in the finished product
Status in the EU
Permitted · Regulation (EU) 2021/2115
Regulated · varies by member state
In short
The major non-intoxicating cannabinoid. Modulates CB1 activity without binding to it directly.
The main intoxicating cannabinoid of cannabis, and the molecule the French legal threshold is written against.
Method and limits
The fifteen compared molecules are the major phytocannabinoids plus the semi-synthetics France scheduled in 2023 and 2024. Every field is read from the corresponding Canna·wiki record, which cites its primary sources and its verification date.
Legal statuses summarise the French and EU position at the date shown on each record. When a molecule is scheduled by name (HHC, HHC-P, H4-CBD since the ANSM decision of June 2023), the record is the reference, not the summary here.