Cannabinoid comparator
Two Canna·wiki molecules side by side: formula, origin, receptors and legal status, straight from the encyclopedia records.
CBD
Cannabidiol
Δ9-THC
Delta-9-tétrahydrocannabinol
Molecular formula
C₂₁H₃₀O₂
C₂₁H₃₀O₂
Identification
1940
1964
Origin
Plante
Plante
Receptors
Modulateur allostérique négatif de CB1 (Ki > 10 µM), agoniste 5-HT1A (Ki ≈ 16 µM), agoniste TRPV1 (EC50 ≈ 3,5 µM), antagoniste GPR55
Agoniste partiel CB1 (Ki ≈ 40,7 nM, Emax ≈ 40 %) et CB2 (Ki ≈ 36 nM)
Status in France
Autorisé · usage adulte
Stupéfiant : Arrêté du 22 février 1990
Status in the EU
Autorisé · règlement (UE) 2021/2115
Convention 1971 · Annexe II : seuil produit fini 0,3 %
In short
Le cannabinoïde majeur non psychotrope. Module l'activité de CB1 sans s'y fixer directement.
Le cannabinoïde de référence - base de la pharmacologie cannabique moderne (Mechoulam & Gaoni, 1964).
Method and limits
The fifteen compared molecules are the major phytocannabinoids plus the semi-synthetics France scheduled in 2023 and 2024. Every field is read from the corresponding Canna·wiki record, which cites its primary sources and its verification date.
Legal statuses summarise the French and EU position at the date shown on each record. When a molecule is scheduled by name (HHC, HHC-P, H4-CBD since the ANSM decision of June 2023), the record is the reference, not the summary here.