AM-2201AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole)

[1-(5-fluoropentyl)-1H-indol-3-yl](naphthalen-1-yl)methanone

Aliases.1-(5-fluoropentyl)-3-(1-naphthoyl)indole

Fluorinated analogue of JWH-018, ≈ 9× more potent. Second wave of the Spice market (2010-2012).

Updated on 1 May 2026

Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

Identifiers

Formula: C₂₄H₂₂FNO
Molar mass: 359.44 g·mol⁻¹
CAS: 335161-24-5
PubChem CID: 53393997
First described: 2001
Origin: Pharmaceutical research (Makriyannis, UMass)
InChIKey: ALQFAGFPQCBPED-UHFFFAOYSA-N

In plain terms

AM-2201 is an "improved" version of JWH-018 - more potent still and more dangerous. Present in second-generation "Spice" mixtures.

Receptors and activity

CB1
Ki ≈ 1,0 nMAgonist
CB2
Ki ≈ 2,6 nMAgonist

Agonist
Partial agonist
Antagonist
Modulator
Inverse agonist

Hover over a row for the precise value (Ki, EC50…)

Subjective signature

Hover over an axis to read its definition.

Calm
30
Clarity
20
Sleep
50
Appetite
55
High
95

Editorial estimate, not clinical.

Pharmacology

AM-2201 is the fluorinated (5-fluoropentyl) analogue of JWH-018, synthesised within the SAR programme of the Alexandros Makriyannis group (UMass, 2000s). The terminal fluorine increases lipophilicity and brain penetration: in vivo it is ≈ 9× more potent than JWH-018 (Wiley et al. 2014). It appeared on the illicit European market in 2010-2012 as a replacement for the controlled JWH-018. Severe convulsions and tachycardia are documented (Schneir and Baumbacher 2012, PMID 22463729). Listed in Annex IV in France by the **Decree of 27 July 2012** (NOR AFSP1230815A).

Key sources.