Skip to content

Batch information on every product pageTHC < 0.3%Shipped from France10% off when you sign up

Synthetic

AM-2201Also known as 1-(5-fluoropentyl)-3-(1-naphthoyl)indole

A fluorinated analogue of JWH-018, agonist at CB1 and CB2; a narcotic in France, Schedule II of the 1971 Convention.

Narcotic: named in schedule
Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

C₂₄H₂₂FNO

CAS 335161-24-5

Family
Synthetic CB receptor agonistNew psychoactive substance
Molar mass
359.44 g/mol

Updated on

In plain terms

AM-2201 is a synthetic cannabinoid close to JWH-018: it differs by a fluorine atom at the end of the pentyl chain. It has been found in smoking products sold as « spice ». It is a narcotic in France and is listed in Schedule II of the 1971 Convention.

Receptors and activity

Target network

CB1Agonistno measured value
  • Activates

The lower the cited value, the closer the target sits to AM-2201: one ring per factor of 100. A target with no measured value stays on the edge.

Where these targets live

Where each target has been found in humans, according to the cited studies. The map shows the target, not an effect of AM-2201.

Brain, side view
Body, front view
Blood

CB1CB1 found in 7 regions of the body

  1. Basal gangliadenseMost dense in basal ganglia outflow nuclei1
  2. CerebellumdenseVery dense in the cerebellum1
  3. HippocampusdenseVery high concentrations in the hippocampus2
  4. AmygdaladenseHigh concentrations in the amygdala2
  5. CortexpresentPresent throughout the neocortex2
  6. Adipose tissuepresentExpressed in adipose tissue3
  7. GutpresentColonic epithelium, smooth muscle and plexus4

Map sources

  1. Herkenham M et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A, 1990 (new tab)
  2. Glass M et al. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience, 1997 (new tab)
  3. Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes, 2005 (new tab)
  4. Wright K et al. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology, 2005 (new tab)

Cited values

  1. CB1Agonistno measured value cited
  2. CB2Agonistno measured value cited
Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

Pharmacology

AM-2201 [1-(5-fluoropentyl)-3-(1-naphthoyl)indole] is the 5-fluoropentyl derivative of JWH-018: the same naphthoylindole skeleton, with a fluorine atom at the end of the chain. It activates human CB1 and CB2 receptors. In the comparison by Banister et al. (2015), terminally fluorinated analogues were generally 2 to 5 times more potent at CB1 than their non-fluorinated counterparts in vitro, but this trend was not found in vivo: in rats, the hypothermia induced ranked JWH-018 ahead of AM-2201. A case report (Schneir and Baumbacher 2012) describes two generalised convulsions in a patient after use of a « spice » product in which four synthetic cannabinoids, including AM-2201, were confirmed. AM-2201 has been in Schedule II of the 1971 Convention since CND decision 58/11 (13 March 2015) and is in Annex IV of the French list of narcotics.

Key sources.

History

Source
A laboratory naphthoylindole, a fluorinated analogue of JWH-018, found in smoking products sold as « spice »

Origin

Laboratory synthesis

Naphthoylindole: the JWH-018 skeleton with a fluorine atom at the end of the N-pentyl chain (IUPAC name: [1-(5-fluoropentyl)-1H-indol-3-yl](naphthalen-1-yl)methanone)

Classification

Family, origin and source verification

Family

Synthetic CB receptor agonist › New psychoactive substance

Class

naphthoylindole

Verification

Classification, sources and binding values checked on 20 October 2026; text read against its sources and Wikipedia.

Wikipedia (English)

AM-2201 (new tab)

Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

References

  1. Banister · ACS Chem Neurosci 2015 (new tab)PMID 25921407
  2. Schneir and Baumbacher · J Med Toxicol 2012 (new tab)PMID 22160733

Identifiers

Names

Common name
AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole)
IUPAC name
[1-(5-fluoropentyl)indol-3-yl]-naphthalen-1-ylmethanone
Other names
JWH-2201 · 1-(5-fluoropentyl)-3-(1-naphthoyl)indole

Identifiers

Formula
C₂₄H₂₂FNO
CAS
335161-24-5
PubChem CID
53393997(new tab)
InChIKey
ALQFAGFPQCBPED-UHFFFAOYSA-N
SMILES
C1=CC=C2C(=C1)C=CC=C2C(=O)C3=CN(C4=CC=CC=C43)CCCCCF

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.