EAM-2201

EAM-2201 is a synthetic cannabinoid of the naphthoylindole family, the 5-fluorinated analogue of JWH-210. In the study by Marusich et al. (2018), its affinity is 0.41 nM at CB1 and 0.38 nM at CB2, and its maximal stimulation of CB1 exceeds that of CP55,940 (270.3% against 163.3% above basal); Costain et al. (2016) rank it among the full CB1 agonists. In mice, it substitutes for THC in a discrimination task with an ED50 of 0.04 µmol/kg, the most potent of the batch tested, although its dose-response curve is not monotonic. Human data are limited to forensic observations: a death from diabetic ketoacidosis in which eleven synthetic cannabinoids, including EAM-2201, were detected in blood (Hess et al., 2015), and a fatal case of intoxication by a mixture combining EAM-2201 with two other synthetic cannabinoids and α-PVP (Yamagishi et al., 2018). No therapeutic use is documented in the sources consulted, and no controlled clinical trial has been published in them.

Source

Synthetic molecule: no natural occurrence is reported in the sources consulted. It has been found in illicit products, notably in Japan, where Uchiyama et al. (2013) list it among twelve newly distributed cannabimimetic compounds.

No biosynthetic pathway is reported: EAM-2201 is not reported from any hemp chemotype or living organism. It belongs to chemical synthesis alone, within the naphthoylindole class.

European Union

No harmonised European Union control measure has been identified in the sources consulted, so control rests on national law. At international level, EAM-2201 is not on the INCB green list for 2026, which reproduces the schedules of the 1971 Convention.

France

A narcotic in France, by generic clause and not by name. EAM-2201 is not named in the consolidated list of narcotics published by the ANSM, updated to 16 February 2026. It falls under the indol-3-yl methanone family of annex IV of the ANSM consolidated list, which covers any molecule bearing on the indole nitrogen an alkyl or haloalkyl substituent, and on the carbon of the methanone bridge a naphthyl group, substituted or not. EAM-2201 meets both conditions point by point: a fluorinated pentyl chain on the nitrogen, and a naphthyl bearing an ethyl group on the methanone bridge. JWH-210, from which it differs only by that fluorine, is named in the same annex. This molecule has no place in the CBD trade.

Sources: EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA. Our method.

1. 1Marusich et coll., Neuropharmacology, 2018 : affinités CB1 et CB2, activation de la [35S]GTPγS et substitution au THC pour l'EAM-2201 (tableau 1) (new tab)PMID 29113898
2. 2Costain et coll., Eur J Pharmacol, 2016 : caractérisation pharmacologique des cannabinoïdes de synthèse émergents dans des cellules HEK293T (new tab)PMID 27260125
3. 3Cannaert et coll., Analytical Chemistry, 2016 : activité des cannabinoïdes de synthèse et de leurs métabolites dans un test de bioactivité, dont l'EAM-2201 (new tab)PMID 27779402
4. 4Kim et coll., J Pharm Biomed Anal, 2016 : métabolisme in vitro de l'EAM-2201 sur microsomes hépatiques humains et CYP recombinants (new tab)PMID 26641707
5. 5Kong et coll., Molecules, 2018 : inhibition in vitro des CYP et des UGT par l'EAM-2201 sur microsomes hépatiques humains (new tab)PMID 29659506
6. 6Yamagishi et coll., Legal Medicine, 2018 : cas mortel associant EAM-2201, AB-PINACA, AB-FUBINACA et α-PVP, avec dosages sanguins et tissulaires (new tab)PMID 30268690
7. 7Hess et coll., Forensic Science International, 2015 : décès par cétoacidose diabétique et cannabinoïdes de synthèse (new tab)PMID 26363623
8. 8Uchiyama et coll., Forensic Science International, 2013 : douze cannabimimétiques détectés dans des produits illicites au Japon, dont l'EAM-2201 (new tab)PMID 23063179
9. 9Kakehashi et coll., Forensic Science International, 2020 : concentrations sanguines et urinaires de cannabinoïdes de synthèse chez des conducteurs impliqués dans des accidents (new tab)PMID 31902661
10. 10ANSM, Liste consolidée des substances classées comme stupéfiants (mise à jour du 16 février 2026), annexe IV, famille des indol-3-yl méthanones (new tab)
11. 11INCB, Liste verte 2026 des substances sous contrôle international (tableaux de la convention de 1971) (new tab)
12. 12PubChem, CID 71308187 (EAM-2201) : formule, masse moléculaire moyenne et InChIKey (new tab)

SMILES

CCC1=CC=C(C2=CC=CC=C12)C(=O)C3=CN(C4=CC=CC=C43)CCCCCF

InChIKey

NSCXPXDWLZORPX-UHFFFAOYSA-N

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.