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Derived from the plant

HHC-PHexahydrocannabiphorol (HHC-P)

Heptyl (C7) homologue of HHC, of uncertain origin. More potent than HHC at the CB1 receptor in vitro. A narcotic in France since 13 June 2023.

FranceNarcotic: named in scheduleInternationalNarcotic: generic clause
Level of detail

C₂₃H₃₆O₂

CID 175224422

Family
Semi-synthetic cannabinoidHydrogenated
Molar mass
344.50 g/mol

Updated on

In plain terms

HHC-P is a version of HHC whose side chain has 7 carbons instead of 5. In the laboratory, it activates the CB1 receptor at a lower concentration than HHC, and its 9R form is the most active. It has been classified as a narcotic in France since June 2023.

Receptors and activity

Target network

CB1 ((9R)-HHC-P)Partial agonistEC50 = 44.4 nM · humanFunctional activation (AequoScreen, luminescence), CHO-K1-hCB1; efficacy 61% of JWH-018
  • Activates

The lower the cited value, the closer the target sits to HHC-P: one ring per factor of 100. A target with no measured value stays on the edge.

Where these targets live

Where each target has been found in humans, according to the cited studies. The map shows the target, not an effect of HHC-P.

Brain, side view
Body, front view
Blood

CB1CB1 found in 7 regions of the body

  1. Basal gangliadenseMost dense in basal ganglia outflow nuclei1
  2. CerebellumdenseVery dense in the cerebellum1
  3. HippocampusdenseVery high concentrations in the hippocampus2
  4. AmygdaladenseHigh concentrations in the amygdala2
  5. CortexpresentPresent throughout the neocortex2
  6. Adipose tissuepresentExpressed in adipose tissue3
  7. GutpresentColonic epithelium, smooth muscle and plexus4

Map sources

  1. Herkenham M et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A, 1990 (new tab)
  2. Glass M et al. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience, 1997 (new tab)
  3. Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes, 2005 (new tab)
  4. Wright K et al. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology, 2005 (new tab)

Cited values

  1. CB1 ((9R)-HHC-P)Partial agonistEC50 = 44.4 nM · human56 out of 100

    Persson M et al. Drug Test Anal 2025;17:487-493 (new tab) · Functional activation (AequoScreen, luminescence), CHO-K1-hCB1; efficacy 61% of JWH-018

  2. CB1 ((9S)-HHC-P)Partial agonistEC50 = 134 nM · human48 out of 100

    Persson M et al. Drug Test Anal 2025;17:487-493 (new tab) · Functional activation (AequoScreen, luminescence), CHO-K1-hCB1; efficacy 66% of JWH-018

Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

Pharmacology

HHC-P (hexahydrocannabiphorol) is the heptyl (C7) homologue of HHC, just as THCP is that of THC. It was described as early as 1942 in Roger Adams's work on THC homologues; products claiming to contain HHC-P have been sold online since 2021, and its first identification in Europe comes from a Slovenian seizure of November 2022. Its origin remains uncertain: the 9R and 9S epimers found in a Japanese cartridge are consistent with a reduction of Δ9-THCP (Tanaka and Kikura-Hanajiri, 2024), but a Swiss sample contained by-products unknown in cannabis, a sign of total synthesis (Schirmer et al., 2025). In a functional assay at human CB1 (CHO-K1 cells), (9R)-HHC-P showed an EC50 of 44.4 nM and (9S)-HHC-P of 134 nM, against 101 nM and 1190 nM for the HHC epimers; all behaved as partial agonists (Persson et al., 2025). Market products are mixtures of epimers (diastereomers), not racemates. In humans, HHC-P is extensively metabolised (hydroxylations on the side chain and the alicyclic part, then glucuronidation); after a single oral dose of 4 mg, urinary cannabis immunoassays remained negative (Schirmer et al., 2025). No controlled human study has been published. HHC-P has been classified by name as a narcotic in France since 13 June 2023; it is not covered by the international listing of HHC (CND decision 68/5).

Key sources.

History

Source
Semi-synthetic by convention; uncertain origin, possibly fully synthetic

Route of preparation

Chemical process

No known biosynthesis: HHC-P is not described as a natural constituent of cannabis. Market products are presented as the hydrogenated derivative of THCP, a C7 homologue present in trace amounts in the plant (EMCDDA 2023); a sample from the Swiss market, however, contained by-products (« abnormal » and bis-alkylated cannabinoids) unknown in cannabis, a sign of fully synthetic production (Schirmer et al., 2025).

Classification

Family, origin and source verification

Family

Semi-synthetic cannabinoid › Hydrogenated

Chemistry

C7 side chain · neutral form

Verification

Every fact on this entry was checked against its primary sources on 20 October 2026.

Wikipedia (English)

Hexahydrocannabiphorol (new tab)

Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

References

  1. Persson M et al. In vitro activation of the CB1 receptor by HHC, HHC-O and HHC-P. Drug Test Anal 2025;17:487-493 (new tab)PMID 38894658
  2. Schirmer W et al. Isolation and characterization of synthesis intermediates and side products in hexahydrocannabiphorol. Drug Test Anal 2025;17:531-543 (new tab)PMID 38948934
  3. Schirmer W et al. Identification of hexahydrocannabiphorol metabolites in human urine. Drug Test Anal 2025;17:1681-1693 (new tab)PMID 39981602
  4. Tanaka R, Kikura-Hanajiri R. Identification of HHC, dihydro-iso-THC and HHCP in electronic cigarette cartridge products. Forensic Toxicol 2024;42:71-81 (new tab)PMID 37365398
  5. EMCDDA (Ujváry et al.), Hexahydrocannabinol (HHC) and related substances, 2023 (new tab)
  6. ANSM, decision of 12/06/2023 amending the list of substances classified as narcotics (new tab)

Identifiers

Names

Common name
Hexahydrocannabiphorol (HHC-P)
IUPAC name
(6aR,10aR)-3-heptyl-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
Other names
HHCP · HHC-C7

Identifiers

Formula
C₂₃H₃₆O₂
PubChem CID
175224422(new tab)
InChIKey
USZILQYXSONCHH-VOBHOPKGSA-N
SMILES
CCCCCCCC1=CC(=C2[C@@H]3CC(CC[C@H]3C(OC2=C1)(C)C)C)O

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.