JWH-057

JWH-057, or 1-deoxy-Δ8-THC-DMH, is a synthetic cannabinoid designated by the JWH code, used in the work of John W. Huffman at Clemson University. It is an analogue of Δ8-THC that lacks a hydroxyl at position 1, and whose side chain at position 3 is a 1′,1′-dimethylheptyl. Huffman et al. (2010) report an affinity constant of Ki 23 ± 7 nM for CB1 and Ki 2.9 ± 1.6 nM for CB2, a selectivity of nearly ten-fold for CB2. The authors describe it as potent in vivo. No human data were found in the sources consulted, and no therapeutic indication is established. In France, it falls under a generic clause of the narcotics list.

Source

Synthetic molecule designed in laboratories studying cannabinoid receptors, with no established therapeutic indication. No source consulted reports it in hemp or in any other living organism. It appears in the literature around 1996, in parallel with the work of Huffman's team at Clemson University.

No biosynthetic pathway: JWH-057 is produced by no living organism identified in the sources consulted. It belongs to chemical synthesis alone, which assembles a partially hydrogenated benzo[c]chromene nucleus and a 1′,1′-dimethylheptyl side chain on the aromatic ring.

European Union

No harmonised control measure at European Union level was found in the sources consulted: control therefore falls under national legislation. The molecule is not on the INCB Green List 2026, which reproduces the 1961 and 1971 conventions.

France

Substance not named in the consolidated list of narcotics (updated 16 February 2026), but covered by a generic clause. It falls under the clause on derivatives of the benzo[c]chromene nucleus, figuring in annex IV of the decree of 22 February 1990 in the wording resulting from the decisions of 22 May 2024 and 3 June 2024. This clause covers any substance derived from this nucleus, unhydrogenated, partially or fully hydrogenated on the ring bearing the methyl at position 9, and substituted or not at positions 1, 2, 3, 4, 6 and 9 according to the types listed. JWH-057 meets each of these conditions: a partially hydrogenated benzo[c]chromene nucleus on this ring, a branched alkyl chain at position 3, two alkyl groups at position 6 and one alkyl group at position 9. It falls under none of the clause's exclusions (CBN, CBNA, THCV, THCA). Its production, possession, transfer and use therefore fall under the criminal narcotics regime. It therefore cannot be legally sold in France.

Sources: EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA. Our method.

1. 1Huffman et coll., 1-bromo-1-désoxy-Δ8-THC sélectifs du récepteur CB2 (série des 3-(1′,1′-diméthylalkyl) analogues), Bioorg Med Chem, 2010 (new tab)PMID 20943404
2. 2Huffman, recherche de ligands sélectifs du récepteur CB2 (revue), Current Pharmaceutical Design, 2000 (new tab)PMID 10903395
3. 3Gareau et coll., relations structure-activité des analogues du tétrahydrocannabinol sur les récepteurs cannabinoïdes humains, Bioorg Med Chem Lett, 1996 (new tab)DOI 10.1016/0960-894X(95)00573-C
4. 4ChEMBL, CHEMBL57723 (mesures de liaison CB1 et CB2 du JWH-057) (new tab)
5. 5PubChem, CID 129128 (JWH-057) (new tab)
6. 6ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (annexe IV, clause benzo[c]chromène) (new tab)
7. 7ANSM, décision du 22 mai 2024 modifiant la liste des substances classées comme stupéfiants (new tab)
8. 8OICS, Green List 2026 (conventions de 1961 et 1971) (new tab)

SMILES

CCCCCCC(C)(C)C1=CC2=C(C=C1)[C@@H]3CC(=CC[C@H]3C(O2)(C)C)C

InChIKey

JEEFMLVJZKFOFV-FCHUYYIVSA-N

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.