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Synthetic

5F-MDMB-PINACAAlso known as 5F-ADB

A fluorinated indazole-3-carboxamide, a potent agonist at CB1 and CB2; in Schedule II of the 1971 Convention since 2018, a narcotic in France.

Narcotic: named in schedule
Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

C₂₀H₂₈FN₃O₃

CAS 1715016-75-3

Family
Synthetic CB receptor agonistNew psychoactive substance
Molar mass
377.46 g/mol

Updated on

In plain terms

5F-MDMB-PINACA (5F-ADB) is a synthetic cannabinoid of the indazole-3-carboxamide family. It activates CB1 and CB2 receptors more strongly than THC. It has been in Schedule II of the 1971 Convention since 2018 and is a narcotic in France.

Receptors and activity

Target network

CB1AgonistEC50 = 0.6 nM · humanmembrane potential (FLIPR), Emax 108%
  • Activates

The lower the cited value, the closer the target sits to 5F-MDMB-PINACA: one ring per factor of 100. A target with no measured value stays on the edge.

Where these targets live

Where each target has been found in humans, according to the cited studies. The map shows the target, not an effect of 5F-MDMB-PINACA.

Brain, side view
Body, front view
Blood

CB1CB1 found in 7 regions of the body

  1. Basal gangliadenseMost dense in basal ganglia outflow nuclei1
  2. CerebellumdenseVery dense in the cerebellum1
  3. HippocampusdenseVery high concentrations in the hippocampus2
  4. AmygdaladenseHigh concentrations in the amygdala2
  5. CortexpresentPresent throughout the neocortex2
  6. Adipose tissuepresentExpressed in adipose tissue3
  7. GutpresentColonic epithelium, smooth muscle and plexus4

Map sources

  1. Herkenham M et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A, 1990 (new tab)
  2. Glass M et al. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience, 1997 (new tab)
  3. Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes, 2005 (new tab)
  4. Wright K et al. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology, 2005 (new tab)

Cited values

  1. CB1AgonistEC50 = 0.6 nM · human87 out of 100

    Banister et al. 2016, ACS Chem Neurosci (value reported by WHO, 42nd ECDD, 2019) (new tab) · membrane potential (FLIPR), Emax 108%

  2. CB2AgonistEC50 = 7.5 nM · human69 out of 100

    Banister et al. 2016, ACS Chem Neurosci (value reported by WHO, 42nd ECDD, 2019) (new tab) · membrane potential (FLIPR), Emax 94%

Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

Pharmacology

5F-MDMB-PINACA (5F-ADB) is an indazole-3-carboxamide: an indazole substituted on the nitrogen by a 5-fluoropentyl group and, at position 3, by a carboxamide linked to the methyl ester of L-tert-leucine. Banister et al. (2016) synthesised and tested it: a potent, highly efficacious agonist at CB1 and CB2 receptors, more potent than Δ9-THC and than earlier generations (EC50 of 0.45 to 36 nM at CB1 across all compounds in the study). Angerer et al. (2017) describe three deaths involving 5F-PB-22, AB-CHMINACA and 5F-ADB respectively, stressing that the blood concentration of a synthetic cannabinoid is not enough on its own to conclude on the cause of death. It has been in Schedule II of the 1971 Convention since CND decision 61/8 (14 March 2018) and is in Annex III of the French list of narcotics.

Key sources.

History

Source
Designer-drug market (academic origin not established by the sources consulted)

Origin

Laboratory synthesis

Indazole-3-carboxamide: an indazole substituted on the nitrogen by a 5-fluoropentyl group and, at position 3, by a carboxamide linked to the methyl ester of L-tert-leucine

Classification

Family, origin and source verification

Family

Synthetic CB receptor agonist › New psychoactive substance

Class

indazole-3-carboxamide

Verification

Classification, sources and binding values checked on 20 October 2026; text read against its sources and Wikipedia.

Wikipedia (English)

5F-ADB (new tab)

Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

References

  1. Banister · ACS Chem Neurosci 2016 (new tab)PMID 27421060
  2. Sommer · Addiction 2026 (new tab)PMID 41423817
  3. Angerer · Forensic Sci Int 2017 (new tab)PMID 29133010

Identifiers

Names

Common name
5F-MDMB-PINACA (5F-ADB)
IUPAC name
methyl (2S)-2-[[1-(5-fluoropentyl)indazole-3-carbonyl]amino]-3,3-dimethylbutanoate
Other names
5F-ADB

Identifiers

Formula
C₂₀H₂₈FN₃O₃
CAS
1715016-75-3
PubChem CID
121491649(new tab)
InChIKey
PWEKNGSNNAKWBL-QGZVFWFLSA-N
SMILES
CC(C)(C)[C@@H](C(=O)OC)NC(=O)C1=NN(C2=CC=CC=C21)CCCCCF

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.