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From the plant

Cannabiglendol

Cannabinoid with a bridged skeleton and a propyl chain, isolated in 1981; pharmacology not studied.

Unscheduled
Level of detail

C₁₉H₂₈O₃

CAS 77091-08-8

Family
PhytocannabinoidMinor
Origin
Origin not established
Molar mass
304.40 g/mol

Updated on

In plain terms

Cannabiglendol is a rare cannabinoid, isolated in 1981 from an Indian variety of cannabis. Its bridged, short-chain structure differs clearly from that of THC. Its effects have never been studied.

Receptors and activity

    Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

    Measured effects

    Not characterised. No placebo-controlled human trial has measured the effects of Cannabiglendol, so no level is shown.

    Levels computed from placebo-controlled human trials: difference from placebo on 100, at the dose and route stated. Read the method

    Pharmacology

    Cannabiglendol (8-hydroxy-isohexahydrocannabivarin, OH-iso-HHCV-C3) is a « miscellaneous » cannabinoid according to Radwan et al. (2021): a bridged 2,6-methano-2H-1-benzoxocine skeleton of the iso-THC type, carrying a tertiary alcohol and a propyl (C3) side chain. It was isolated and characterised in 1981 from an Indian variety of Cannabis sativa (Turner, Mole, Hanuš and ElSohly, Journal of Natural Products); no other experimental study was found. Its origin in the plant is not established. No CB1 or CB2 affinity and no pharmacokinetic, metabolism or toxicology data have been published, and no human data exist.

    Key sources.

    History

    Source
    Cannabis sativa L.: isolated from an Indian variety (Turner et al. 1981). Origin not established: no source consulted says whether the plant produces it or whether it forms after harvest.

    Biosynthetic pathway

    No formation pathway has been described and no enzyme is associated with it. Its propyl (C3) side chain links it structurally to the varin series, but this relationship has not been studied.

    Classification

    Family, origin and source verification

    Family

    Phytocannabinoid › Minor

    Presence in the plant

    Present in the plant; origin not established

    Chemistry

    Type divers (OH-iso-HHCV) · C3 side chain · neutral form

    Verification

    Every fact on this entry was checked against its primary sources on 20 October 2026.

    Wikipedia (English)

    No dedicated article.

    References

    1. Turner C.E., Mole M.L., Hanuš L., ElSohly H.N. 1981, J Nat Prod 44:27-33: Constituents of Cannabis sativa. XIX, isolation and structure of cannabiglendol (new tab)DOI 10.1021/np50013a005
    2. Radwan M.M. et al. 2021, Molecules 26:2774: cannabinoid inventory, miscellaneous type (OH-iso-HHCV-C3) (new tab)PMID 34066753
    3. PubChem CID 156998: cannabiglendol (identifiers) (new tab)
    4. ANSM, consolidated list of substances classified as narcotics, updated 26/06/2026 (new tab)

    Identifiers

    Names

    IUPAC name
    12-(2-hydroxypropan-2-yl)-9-methyl-5-propyl-8-oxatricyclo[7.3.1.02,7]trideca-2,4,6-trien-3-ol
    Other names
    cannabiglendol-C3 · OH-iso-HHCV · OH-iso-HHCV-C3 · 8-hydroxy-isohexahydrocannabivarine

    Identifiers

    Formula
    C₁₉H₂₈O₃
    CAS
    77091-08-8
    PubChem CID
    156998(new tab)
    InChIKey
    RRQVSLLVCGRJNI-UHFFFAOYSA-N
    SMILES
    CCCC1=CC(=C2C3CC(CCC3C(C)(C)O)(OC2=C1)C)O

    Machine-readable entry (JSON)

    LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.