CHM-081
Synthetic molecule of the naphthoylindole family, analogue of JWH-081, classified as a narcotic in France under a generic clause.
C₂₇H₂₇NO₂
Harm-reduction warning
No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.
Data sheet
Names
- IUPAC name
- [1-(cyclohexylmethyl)indol-3-yl]-(4-methoxynaphthalen-1-yl)methanone
- Other names
- 1-(cyclohexylmethyl)-3-(4-methoxy-1-naphthoyl)indole
Identifiers
- Formula
- C₂₇H₂₇NO₂
- Molar mass
- 397.50 g/mol
- CAS
- 1373876-34-6
- PubChem CID
- 118796420(new tab)
- InChIKey
- LMENRXZOUBANKQ-UHFFFAOYSA-N
Class
- Family
- Synthetic cannabinoid (SCRA)
Updated on
Receptors and activity
- CB1Agonist5 out of 100
Aucune constante d'affinité publiée ; agonisme présumé par analogie avec le JWH-081, non mesuré pour ce composé
- CB2Agonist5 out of 100
Aucune constante d'affinité publiée ; agonisme présumé par analogie avec le JWH-081, non mesuré pour ce composé
Subjective signature
- Calm
- 5 out of 100
- Relaxation of body and mind; reduced mental noise without marked drowsiness.
- Clarity
- 5 out of 100
- Sustained attention and clear thinking; functional lucidity, not euphoria.
- High
- 5 out of 100
- Euphoria and sensory intensity; altered perception of time and space.
- Appetite
- 5 out of 100
- Stimulation of hunger and of taste appreciation (the “munchies” effect).
- Sleep
- 5 out of 100
- Sedative effect: aids sleep onset and the continuity of deep sleep.
Pharmacology
CHM-081 is a synthetic molecule of the naphthoylindole family, an analogue of JWH-081 in which the pentyl chain is replaced by a cyclohexylmethyl group. Blakey et al. (2016) report it in seized plant material packaged as herbal incense. The sources consulted give no affinity constant for CB1 or CB2, and no human pharmacokinetic or toxicological data. Its status in France rests on the generic clause of the indol-3-yl methanone family, not on a named mention.
Key sources.
- Blakey K. et coll., identification du QMPSB et d'autres drogues de synthèse dans les mélanges à fumer (herbal incense), Forensic Science International, 2016 (new tab)PMID 26795397
- ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026, annexe IV, famille des indol-3-yl méthanones (new tab)
- INCB, Green List 2026 (substances des conventions de 1971) (new tab)
- PubChem, CID 118796420, [1-(cyclohexylmethyl)indol-3-yl]-(4-methoxynaphthalen-1-yl)methanone (new tab)
History
- Source
- Synthetic molecule: no source consulted reports it in a plant or a living organism. It has been reported in seized plant material packaged as herbal incense.
Origin (pharmaceutical research → illicit market)
No biosynthetic route is described: CHM-081 belongs to synthetic chemistry, through attachment of a naphthoyl group at position 3 of an indole substituted on the nitrogen.
Legal framework
- European Union
No harmonised control measure at European Union level has been identified for this compound in the sources consulted. Control therefore currently falls under the national legislation of member states. At international level, it is not named in the INCB Green List 2026 (annexes of the 1971 Convention).
- France
Substance classified as a narcotic in France through the generic clause of its family, without being named individually. The ANSM consolidated list of 16 February 2026 (annex IV) defines the family of indol-3-yl methanones: a substituent on the indole nitrogen of cycloalkylmethyl type, and a naphthyl group, substituted or not, on the carbon of the methanone bridge. CHM-081 meets both conditions. JWH-081, of which it is the analogue with the N-pentyl chain replaced by a cyclohexylmethyl group, is named in the same annex, which is not the case for CHM-081.
Sources: EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA. Our method.
References
- Blakey K. et coll., identification du QMPSB et d'autres drogues de synthèse dans les mélanges à fumer (herbal incense), Forensic Science International, 2016 (new tab)PMID 26795397
- ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026, annexe IV, famille des indol-3-yl méthanones (new tab)
- INCB, Green List 2026 (substances des conventions de 1971) (new tab)
- PubChem, CID 118796420, [1-(cyclohexylmethyl)indol-3-yl]-(4-methoxynaphthalen-1-yl)methanone (new tab)
Structured data
- SMILES
- COC1=CC=C(C2=CC=CC=C21)C(=O)C3=CN(C4=CC=CC=C43)CC5CCCCC5
- InChIKey
- LMENRXZOUBANKQ-UHFFFAOYSA-N
LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.