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Derived from the plant

HHCHHexahydrocannabihexol

Hydrogenated hexyl (C6) homologue of HHC. A CB1/CB2 agonist in vitro, with no controlled human data.

Narcotic: generic clause
Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

C₂₂H₃₄O₂

CID 175224408

Family
Semi-synthetic cannabinoidHydrogenated
Molar mass
330.50 g/mol

Updated on

In plain terms

HHCH is a version of HHC whose side chain has six carbons instead of five. Made in the laboratory, it activates the cannabinoid receptors in cell culture; no controlled human study exists.

Receptors and activity

Target network

CB1Agonistno measured value
  • Activates

The lower the cited value, the closer the target sits to HHCH: one ring per factor of 100. A target with no measured value stays on the edge.

Where these targets live

Where each target has been found in humans, according to the cited studies. The map shows the target, not an effect of HHCH.

Brain, side view
Body, front view
Blood

CB1CB1 found in 7 regions of the body

  1. Basal gangliadenseMost dense in basal ganglia outflow nuclei1
  2. CerebellumdenseVery dense in the cerebellum1
  3. HippocampusdenseVery high concentrations in the hippocampus2
  4. AmygdaladenseHigh concentrations in the amygdala2
  5. CortexpresentPresent throughout the neocortex2
  6. Adipose tissuepresentExpressed in adipose tissue3
  7. GutpresentColonic epithelium, smooth muscle and plexus4

Map sources

  1. Herkenham M et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A, 1990 (new tab)
  2. Glass M et al. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience, 1997 (new tab)
  3. Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes, 2005 (new tab)
  4. Wright K et al. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology, 2005 (new tab)

Cited values

  1. CB1Agonistno measured value cited
  2. CB2Agonistno measured value cited
Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

Pharmacology

Hexahydrocannabihexol (HHCH, or HHC-H) is the hexyl-chain (C6) homologue of HHC; it corresponds to the hexahydro derivative of THCH, the C6 homologue of THC identified in trace amounts in cannabis (Linciano et al., 2020), but is not itself described as a natural constituent. In vitro, the C4 to C8 homologues of the (9R)- and (9S)-HHC epimers behaved as high-efficacy agonists at the CB1 and CB2 receptors in Gi/o pathways, the 9R epimer being the most potent (Durydivka et al., 2026). Incubated with human liver microsomes, its 9S epimer is mainly hydroxylated on the methylcyclohexyl part, like HHCP (Watanabe et al., 2025). In Sweden, HHC-H reacted with cannabis screening immunoassays in spiking experiments (Helander et al., 2024). No controlled human study has been published. In France, HHCH falls under the generic benzo[c]chromene class in force since 3 June 2024; the Czech Republic listed it by name on 1 July 2024, and the British ACMD recommended in May 2025 that it be placed in Class B.

Key sources.

History

Source
Semi-synthetic by convention (hydrogenated hexyl homologue of HHC); commercial production route not established

Route of preparation

Chemical process

No known biosynthesis: HHCH is not described as a constituent of cannabis. Structurally, it is the hexahydro derivative of tetrahydrocannabihexol (THCH), the C6 homologue of THC identified in trace amounts in cannabis (Linciano et al., 2020); no open source specifies the production route of commercial products.

Classification

Family, origin and source verification

Family

Semi-synthetic cannabinoid › Hydrogenated

Chemistry

C6 side chain · neutral form

Verification

Every fact on this entry was checked against its primary sources on 20 October 2026.

Wikipedia (English)

Hexahydrocannabihexol (new tab)

Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

References

  1. Durydivka O et al. Side-chain homologs of Δ9-THC, Δ8-THC and HHC reveal pathway bias at CB1R and CB2R. Mol Neurobiol 2026;63:846 (new tab)PMID 42625116
  2. Watanabe S et al. In vitro metabolic profiling of 18 semi-synthetic cannabinoids—HHC and its analogs. Clin Chem 2025;71:1158-1168 (new tab)PMID 40853012
  3. Helander A et al. Appearance of hexahydrocannabinols as recreational drugs … focus on HHC, HHC-P, HHC-O and HHC-H. Scand J Clin Lab Invest 2024;84:125-132 (new tab)PMID 38619215
  4. Linciano P et al. Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol. Sci Rep 2020 (new tab)PMID 33328530
  5. Nařízení vlády č. 176/2024 Sb. (new tab)
  6. ANSM, decision of 22/05/2024 amending the list of substances classified as narcotics (new tab)

Identifiers

Names

Common name
Hexahydrocannabihexol
IUPAC name
(6aR,10aR)-3-hexyl-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
Other names
HHC-H · HHC-C6 · HHCH

Identifiers

Formula
C₂₂H₃₄O₂
PubChem CID
175224408(new tab)
InChIKey
OKXUDFJPZMVBEH-HSFDIDPMSA-N
SMILES
CCCCCCC1=CC(=C2[C@@H]3CC(CC[C@H]3C(OC2=C1)(C)C)C)O

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.