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Canna·wikiHHCH

Semi-synthetic cannabinoid

Narcotic: generic clause

HHCHHexahydrocannabihexol

(6aR,10aR)-3-hexyl-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol

Aliases.HHC-H · HHC hexyle · HHCH

Semi-synthetic hexyl (C6) homologue of HHC, a designer drug monitored by the EUDA since 2023.

Updated on

Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

Identifiers

Formula
C₂₂H₃₄O₂
Molar mass
330.50 g·mol⁻¹
CAS
-
PubChem CID
175224408
First described
Synthétisé dès 1942 par Roger Adams dans sa série d'homologues de la chaîne latérale ; réapparu sur le marché européen comme designer drug, d'abord repéré en Suède en septembre 2023 et signalé à l'Agence de l'Union européenne sur les drogues (EUDA).
Origin
Hexyl-chain (C6) homologue of hexahydrocannabinol (HHC), obtained semi-synthetically from hydrogenated cannabinoid precursors.
InChIKey
OKXUDFJPZMVBEH-HSFDIDPMSA-N

In plain terms

A synthetic cousin of HHC, with a longer side chain, recently appeared on the synthetic cannabinoid market.

Receptors and activity

  • CB1
    Agonist
  • CB2
    Agonist
  • Agonist
  • Partial agonist
  • Antagonist
  • Modulator
  • Inverse agonist

Hover over a row for the precise value (Ki, EC50…)

Subjective signature

Hover over an axis to read its definition.

  • Calm
    45
  • Clarity
    20
  • Sleep
    45
  • Appetite
    50
  • High
    65

Editorial estimate, not clinical.

Pharmacology

Hexahydrocannabihexol (HHCH) is a semi-synthetic cannabinoid, the hexyl (C6) homologue of hexahydrocannabinol (HHC). Described as early as 1942 by Roger Adams, who already noted that the hexyl homologue was more potent than the pentyl or heptyl chains, it has resurfaced as a designer drug, first identified in Sweden in September 2023 and then monitored by the EUDA. Like HHC, it acts as an agonist at the CB1 receptors, the psychotropic activity being carried by the 9(R) epimer. Its characterised human data remain very limited, which calls for caution.

Key sources.

Route of preparation (chemical process)

Semi-synthetic route of production: catalytic hydrogenation of the terpenic nucleus of a cannabinoid precursor of the tetrahydrocannabihexol type (hexyl C6 side chain), which saturates the double bond and turns the skeleton into a hexahydro-benzo[c]chromene nucleus. The product is a mixture of the two epimers 9(R) and 9(S).

Structural classification

Class
Semi-synthetic cannabinoid
Origin
Hexyl-chain (C6) homologue of hexahydrocannabinol (HHC), obtained semi-synthetically from hydrogenated cannabinoid precursors.
Status
Narcotic: generic clause

Cannabinoïde hexahydro-dibenzopyranique (noyau benzo[c]chromène entièrement hydrogéné sur le cycle C), homologue du HHC portant une chaîne latérale hexyle à six carbones au lieu du pentyle.

References

  1. 1.Hexahydrocannabihexol : Wikipedia
  2. 2.HHCH : New Drug Monograph, NPS Discovery (CFSRE)
  3. 3.Hexahydrocannabinol (HHC) and related substances : EUDA technical report
  4. 4.Décision du 22/05/2024 modifiant la liste des substances classées comme stupéfiants : ANSM

Structured data

InChIKey
OKXUDFJPZMVBEH-HSFDIDPMSA-N
SMILES
CCCCCCC1=CC(=C2[C@@H]3CC(CC[C@H]3C(OC2=C1)(C)C)C)O
Formula
C22H34O2
Molar mass
330.50 g·mol⁻¹
PubChem CID
175224408
Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.

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