HHCP-OHexahydrocannabiphorol acetate
Acetate ester of HHCP, probably a prodrug of HHCP. A narcotic in France since 3 June 2024.
Harm-reduction warning
No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.
C₂₅H₃₈O₃
CID 177841653
- Family
- Semi-synthetic cannabinoidEster or prodrug
- Molar mass
- 386.60 g/mol
Updated on
In plain terms
HHCP-O is an acetylated version of HHCP, made in the laboratory. Human liver cells rapidly turn it into HHCP. It has been classified as a narcotic in France since June 2024.
Receptors and activity
Pharmacology
HHCP-O (hexahydrocannabiphorol acetate) is the acetate ester of HHCP, the heptyl-chain (C7) homologue of HHC; cannabinoids acylated at the phenol do not occur naturally (EMCDDA 2023). Incubated with human hepatocytes, it is rapidly converted to HHCP and then metabolised like it; its use may not be distinguishable from HHCP use in urine (Lindbom et al., 2025). No direct receptor measurement has been published; by analogy with HHC-O, which barely activates CB1 in vitro (Persson et al., 2025), it probably acts as a prodrug of HHCP. No human study has been published. In France, the ANSM cites it among the substances covered by the generic benzo[c]chromene class in force since 3 June 2024; Spain listed it by name in List II on 23 April 2025.
Key sources.
- Lindbom K et al. Human metabolism of HHC, HHCP and their acetates using hepatocytes and urine samples. Drug Test Anal 2025;17:372-386 (new tab)PMID 38804224
- Watanabe S et al. In vitro metabolic profiling of 18 semi-synthetic cannabinoids—HHC and its analogs. Clin Chem 2025;71:1158-1168 (new tab)PMID 40853012
- Persson M et al. In vitro activation of the CB1 receptor by HHC, HHC-O and HHC-P. Drug Test Anal 2025;17:487-493 (new tab)PMID 38894658
- ANSM, « ANSM adds new cannabinoids to the list of narcotics », 24/05/2024 (updated 11/03/2025) (new tab)
- Orden SND/380/2025, BOE núm. 97 of 22/04/2025 (new tab)
- PubChem CID 177841653: HHCP-O-acetate (new tab)
History
- Source
- Semi-synthetic by convention (acetate ester of HHCP; does not occur naturally)
Route of preparation
Chemical process
No biosynthesis: cannabinoids acylated at the phenol do not occur naturally (EMCDDA 2023). HHCP-O is the acetate ester of HHCP, whose own origin (derived from THCP or total synthesis) is not established. Incubated with human hepatocytes, it is rapidly converted to HHCP (Lindbom et al., 2025).
Legal framework
- European Union
Not named in the UN conventions. Verified national examples: Spain, « acetato de hexahidrocannabiforol (HHCP-O) » in List II (Orden SND/380/2025, in force on 23 April 2025); Germany, generic group of 6H-benzo[c]chromen-1-ol derivatives in the NpSG annex (in force on 27 June 2024). Outside the EU: the British ACMD considers (May 2025) that the acetates would be covered by the « esters and ethers » clause if HHCP were listed. Checked on 19/10/2026.
- France
A narcotic under the generic class of benzo[c]chromene-nucleus derivatives (esterified hydroxyl at position 1), decision of the ANSM Director-General of 22 May 2024, in force on 3 June 2024; the ANSM expressly cites « HHCPO (ou HHCP acétate) » among the substances of this family. Checked on 19/10/2026.
Sources: EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA. Our method.
Classification
Family, origin and source verification
- Family
Semi-synthetic cannabinoid › Ester or prodrug
- Chemistry
C7 side chain · neutral form
- Verification
Every fact on this entry was checked against its primary sources on 20 October 2026.
- Wikipedia (English)
Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.
References
- Lindbom K et al. Human metabolism of HHC, HHCP and their acetates using hepatocytes and urine samples. Drug Test Anal 2025;17:372-386 (new tab)PMID 38804224
- Watanabe S et al. In vitro metabolic profiling of 18 semi-synthetic cannabinoids—HHC and its analogs. Clin Chem 2025;71:1158-1168 (new tab)PMID 40853012
- Persson M et al. In vitro activation of the CB1 receptor by HHC, HHC-O and HHC-P. Drug Test Anal 2025;17:487-493 (new tab)PMID 38894658
- ANSM, « ANSM adds new cannabinoids to the list of narcotics », 24/05/2024 (updated 11/03/2025) (new tab)
- Orden SND/380/2025, BOE núm. 97 of 22/04/2025 (new tab)
- PubChem CID 177841653: HHCP-O-acetate (new tab)
Identifiers
Names
- Common name
- Hexahydrocannabiphorol acetate
- IUPAC name
- [(6aR,10aR)-3-heptyl-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-yl] acetate
- Other names
- HHCPO · HHCP-O-acetate
Identifiers
- Formula
- C₂₅H₃₈O₃
- PubChem CID
- 177841653(new tab)
- InChIKey
- LRVWJGANNJYLTC-LTGQRPFBSA-N
- SMILES
- CCCCCCCC1=
CC2= C([C@@H] 3CC(CC[C@H] 3C(O2) (C) C) C) C(= C1) OC(= O) C
LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.