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Synthetic

HU-210Also known as (-)-11-hydroxy-Δ8-THC-DMH

A classical cannabinoid described in 1988 at the Hebrew University, with very high affinity for CB1; a narcotic in France since 2009.

Narcotic: named in schedule
Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

C₂₅H₃₈O₃

CAS 112830-95-2

Family
Synthetic CB receptor agonistResearch ligand or medicine
First described
1988
Molar mass
386.57 g/mol

Updated on

In plain terms

HU-210 is a synthetic cannabinoid developed at the Hebrew University of Jerusalem. It binds to cannabinoid receptors with very high affinity. It has been a narcotic in France since 2009.

Receptors and activity

Target network

CB1AgonistKi = 0.2 nMcannabinoid receptor binding affinity (value from the abstract)
  • Activates

The lower the cited value, the closer the target sits to HU-210: one ring per factor of 100. A target with no measured value stays on the edge.

Where these targets live

Where each target has been found in humans, according to the cited studies. The map shows the target, not an effect of HU-210.

Brain, side view
Body, front view
Blood

CB1CB1 found in 7 regions of the body

  1. Basal gangliadenseMost dense in basal ganglia outflow nuclei1
  2. CerebellumdenseVery dense in the cerebellum1
  3. HippocampusdenseVery high concentrations in the hippocampus2
  4. AmygdaladenseHigh concentrations in the amygdala2
  5. CortexpresentPresent throughout the neocortex2
  6. Adipose tissuepresentExpressed in adipose tissue3
  7. GutpresentColonic epithelium, smooth muscle and plexus4

Map sources

  1. Herkenham M et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A, 1990 (new tab)
  2. Glass M et al. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience, 1997 (new tab)
  3. Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes, 2005 (new tab)
  4. Wright K et al. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology, 2005 (new tab)

Cited values

  1. CB1AgonistKi = 0.2 nM96 out of 100

    Devane et al. 1992, J Med Chem (new tab) · cannabinoid receptor binding affinity (value from the abstract)

  2. CB2Agonistno measured value cited
Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

Pharmacology

HU-210 is a « classical » cannabinoid (dibenzopyran): the 1,1-dimethylheptyl homologue of 11-hydroxy-Δ8-THC. A 1988 publication from Raphael Mechoulam's group (Hebrew University of Jerusalem) shows that this homologue is strongly psychotropic in mice, rats and pigeons, while its (+) enantiomer is inactive at doses several thousand times higher (Mechoulam et al. 1988). Devane et al. (1992) describe it as the most potent cannabimimetic substance known at the time, with a Ki of 180 pM (0.18 nM) for the cannabinoid receptor; Felder et al. (1995) note a higher affinity for CB1 than for CB2. In France, it was listed as a narcotic by the order of 24 February 2009, together with JWH-018 and CP 47,497, three molecules associated with the « Spice » mixture (ministerial reply to written question no. 42608). It is not in the Schedules of the 1971 Convention.

Key sources.

History

Source
Hebrew University of Jerusalem (Raphael Mechoulam's group)

Origin

Laboratory synthesis

A classical cannabinoid (dibenzopyran): the 1,1-dimethylheptyl analogue of 11-hydroxy-Δ8-THC

Classification

Family, origin and source verification

Family

Synthetic CB receptor agonist › Research ligand or medicine

Class

classical

Verification

Classification, sources and binding values checked on 20 October 2026; text read against its sources and Wikipedia.

Wikipedia (English)

HU-210 (new tab)

Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

References

  1. Mechoulam · Experientia 1988 (new tab)PMID 3416993
  2. Devane · J Med Chem 1992 (new tab)PMID 1317925
  3. Felder · Mol Pharmacol 1995 (new tab)PMID 7565624

Identifiers

Names

Common name
HU-210 ((-)-11-hydroxy-Δ8-THC-DMH)
IUPAC name
(6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Other names
HU210

Identifiers

Formula
C₂₅H₃₈O₃
CAS
112830-95-2
PubChem CID
9821569(new tab)
InChIKey
SSQJFGMEZBFMNV-WOJBJXKFSA-N
SMILES
CCCCCCC(C)(C)C1=CC(=C2[C@@H]3CC(=CC[C@H]3C(OC2=C1)(C)C)CO)O

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.