HU-210HU-210 ((-)-11-hydroxy-Δ8-THC-DMH)

Aliases.HU210 · (6aR,10aR)-9-(hydroxymethyl)-3-(2-methyloctan-2-yl)-...

The most potent cannabinoid ever synthesised in a laboratory. The reference Mechoulam tool compound.

Updated on 1 May 2026

Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

Identifiers

Formula: C₂₅H₃₈O₃
Molar mass: 386.57 g·mol⁻¹
CAS: 112830-95-2
PubChem CID: 9821569
First described: 1988
Origin: Hebrew University of Jerusalem (Mechoulam)
InChIKey: SSQJFGMEZBFMNV-WOJBJXKFSA-N

In plain terms

HU-210 is extremely potent - 100 to 800 times more so than THC. Designed in the laboratory for research, not for human use. Present in some very early "Spice" blends.

Receptors and activity

CB1
Ki ≈ 0,061 nMAgonist
CB2
Ki ≈ 0,52 nMAgonist

Agonist
Partial agonist
Antagonist
Modulator
Inverse agonist

Hover over a row for the precise value (Ki, EC50…)

Subjective signature

Hover over an axis to read its definition.

Calm
25
Clarity
10
Sleep
60
Appetite
60
High
99

Editorial estimate, not clinical.

Pharmacology

HU-210 is the reference cannabinoid of the Mechoulam laboratory (Hebrew University) - synthesised in 1988 (Mechoulam, Lander, Breuer & Zahalka). A 1,1-dimethylheptyl + 11-hydroxy modification of Δ8-THC: Ki = 0.061 nM (CB1, rat brain) - full agonist. Detected briefly in "Spice" blends seized in 2008-2009 but rapidly replaced by SCRAs cheaper to synthesise. France: listed by name in Annex IV by **Decree of 24 February 2009** (NOR SASP0900303A). EU: Council Decision **2009/206/JHA**.

Key sources.