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JW 642

Research inhibitor of MAGL, synthetic molecule with no published human data.

Unscheduled
Level of detail

C₂₁H₂₀F₆N₂O₃

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

Data sheet

Names

IUPAC name
1,1,1,3,3,3-hexafluoropropan-2-yl 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
Other names
JW 642 (Standard) · GLXC-04466 · NCGC00379230-01 · orb1308167

Identifiers

Formula
C₂₁H₂₀F₆N₂O₃
Molar mass
462.40 g/mol
PubChem CID
71656520(new tab)
InChIKey
AVSCNEOUWSVZEY-UHFFFAOYSA-N

Class

Family
ECS modulator (research)

Legal status

Status
Unscheduled
See the legal framework

Updated on

Receptors and activity

  1. MAGL (monoacylglycérol lipase)Modulator68 out of 100

    IC50 74 nM sur la MAGL humaine recombinante (Korhonen et coll., 2014, d'après ChEMBL)

  2. FAAHModulator10 out of 100

    activité résiduelle de 76 % à 10 µM (Korhonen et coll., 2014, d'après ChEMBL) ; aucune CI50 rapportée dans cette source

  3. CB1Modulator5 out of 100

    aucune constante d'affinité publiée dans ChEMBL pour cette molécule

  4. CB2Modulator5 out of 100

    aucune constante d'affinité publiée dans ChEMBL pour cette molécule

Bar length shows the relative strength of the interaction, as an indication.

Subjective signature

Calm
5 out of 100
Relaxation of body and mind; reduced mental noise without marked drowsiness.
Clarity
3 out of 100
Sustained attention and clear thinking; functional lucidity, not euphoria.
High
2 out of 100
Euphoria and sensory intensity; altered perception of time and space.
Appetite
3 out of 100
Stimulation of hunger and of taste appreciation (the “munchies” effect).
Sleep
3 out of 100
Sedative effect: aids sleep onset and the continuity of deep sleep.
Editorial estimate, not clinical.

Pharmacology

JW 642 (hexafluoroisopropyl carbamate of a piperazine substituted by a 3-phenoxybenzyl group) is a synthetic molecule described as a selective inhibitor of monoacylglycerol lipase (MAGL). An IC50 of 74 nM on the recombinant human enzyme is reported in ChEMBL (Korhonen et al., 2014), and the molecule serves as a reference inhibitor in an enzyme assay and as a blocking agent in PET studies in rodents and macaques. The sources consulted publish neither human data nor affinity for CB1 or CB2.

Key sources.

History

Source
Synthetic molecule with no known natural origin. It is described as a selective inhibitor of monoacylglycerol lipase (MAGL) in research studies (Mori et al., 2019).

Origin (research tool)

No biosynthetic pathway: synthetic molecule of the piperazine carbamate class.

References

  1. Hattori et coll., occupation de la MAGL par JW 642 mesurée en TEP chez le macaque, J Cereb Blood Flow Metab 2022 (new tab)PMID 34727758
  2. Mori et coll., radiotraceur TEP de la MAGL testé chez le rongeur, Bioorg Med Chem 2019 (new tab)PMID 31278005
  3. Del Carlo et coll., dosage HPLC/UV de la MAGL recombinante, J Pharm Biomed Anal 2015 (new tab)PMID 25743577
  4. Korhonen et coll., carboxamides et carbamates de pipérazine inhibiteurs de FAAH et MAGL, Bioorg Med Chem 2014 (new tab)PMID 25282655
  5. ChEMBL, CHEMBL3356976 (activités MAGL et FAAH) (new tab)
  6. PubChem, CID 71656520 (JW 642) (new tab)
  7. ANSM, liste consolidée des stupéfiants (mise à jour du 16 février 2026) (new tab)
  8. INCB, Green List 2026 (conventions de 1971) (new tab)

Structured data

SMILES
C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC(C(F)(F)F)C(F)(F)F
InChIKey
AVSCNEOUWSVZEY-UHFFFAOYSA-N

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.