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Research tools

OMDM-1

A laboratory tool that slows the cellular uptake of anandamide.

Unscheduled
Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

C₂₇H₄₅NO₃

CID 10410511

Family
ECS pharmacological toolTransport inhibitor
Molar mass
431.70 g/mol

Updated on

In plain terms

OMDM-1 is a laboratory molecule obtained by chemical synthesis: it does not come from hemp. It is used to slow the uptake of anandamide by cells, a substance the body makes itself. Researchers use it on cells and in animals; it is not a consumer product.

Receptors and activity

Target network

FAAHInhibitorno measured value
  • Blocks or inhibits
  • Binds or modulates

The lower the cited value, the closer the target sits to OMDM-1: one ring per factor of 100. A target with no measured value stays on the edge.

Where these targets live

Where each target has been found in humans, according to the cited studies. The map shows the target, not an effect of OMDM-1.

Brain, side view
Body, front view
Blood

FAAHFAAH found in 7 regions of the body

  1. CortexpresentCortical pyramidal neurons1
  2. Basal gangliapresentStriatal neurons1
  3. HypothalamuspresentPresent in hypothalamic nuclei1
  4. CerebellumpresentPurkinje cells and cerebellar layers1
  5. BrainstempresentInferior olivary nuclei1
  6. Adipose tissuepresentExpressed in mature adipocytes2
  7. BonepresentPresent on osteoclasts3

Map sources

  1. Romero J et al. Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study. Brain Res Mol Brain Res, 2002 (new tab)
  2. Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes, 2005 (new tab)
  3. Rossi F et al. The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. Bone, 2009 (new tab)

Cited values

  1. Recapture cellulaire de l'anandamideInhibitorKi = 2.4 µM · rat27 out of 100

    Ortar et al., Biochem Pharmacol 2003 (new tab) · anandamide reuptake in RBL-2H3 cells (rat line); the putative membrane transporter remains debated

  2. FAAHInhibitorno measured value cited
  3. CB1Binding (function not established)no measured value cited
  4. CB2Binding (function not established)no measured value cited
  5. TRPV1Binding (function not established)no measured value cited
Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

Pharmacology

OMDM-1 is one of the pharmacological tools described in 2003 to study the cellular uptake of anandamide (Ortar et al. 2003). In RBL-2H3 cells it blocks this process with a Ki of 2.4 µM while remaining almost inactive at neighbouring targets (CB1, CB2, VR1, FAAH) and very stable to enzymatic hydrolysis. In rats, 1 to 10 mg/kg intraperitoneally changed none of the five motor parameters measured, with a trend towards reduced ambulation; unlike OMDM-2, OMDM-1 did not strengthen the motor effects of an ineffective dose of anandamide or lengthen the time spent on a hot plate, with a trend towards potentiating the analgesia of anandamide (P = 0.06). At 5 mg/kg intravenously, it reduced hindlimb spasticity in mice with chronic relapsing experimental allergic encephalomyelitis (de Lago et al. 2004). Two reservations apply: the existence of a membrane transporter for anandamide remains debated (Ligresti et al. 2010), and the data cited are preclinical.

Key sources.

History

Source
A synthetic molecule, an aromatic analogue of N-oleoylethanolamine (an amide of oleic acid and a tyrosine-derived amino alcohol), absent from hemp and from any living organism. A research reagent.

Origin

Research tool

No natural biosynthetic pathway: the molecule is formed in no living organism; it is a synthetic oleic acid amide.

Classification

Family, origin and source verification

Family

ECS pharmacological tool › Transport inhibitor

Verification

Classification, sources and binding values checked on 20 October 2026; text read against its sources and Wikipedia.

Wikipedia (English)

No dedicated article.

References

  1. Ortar G, Ligresti A, De Petrocellis L, Morera E, Di Marzo V, Novel selective and metabolically stable inhibitors of anandamide cellular uptake, Biochem Pharmacol 2003 (new tab)PMID 12732359
  2. de Lago E et al., In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake, Eur J Pharmacol 2004 (new tab)PMID 14744610
  3. Ligresti A et al., Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter, PLoS One 2010 (new tab)PMID 20422025
  4. ANSM, Consolidated list of substances classified as narcotics, updated 16 February 2026, annex IV (new tab)
  5. PubChem, (S)-N-oleoyltyrosinol, CID 10410511 (new tab)

Identifiers

Names

IUPAC name
(Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide
Other names
OMDM1 · N-oleoyltyrosinol

Identifiers

Formula
C₂₇H₄₅NO₃
PubChem CID
10410511(new tab)
InChIKey
ICDMLAQPOAVWNH-JRUKXMRZSA-N
SMILES
CCCCCCCC/C=C\CCCCCCCC(=O)N[C@@H](CC1=CC=C(C=C1)O)CO

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.