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Synthetic

5F-SDB-006

Indole-3-carboxamide synthetic cannabinoid, a low-efficacy CB1 agonist; human data absent.

Narcotic: generic clause
Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

C₂₁H₂₃FN₂O

CAS 1776086-02-2

Family
Synthetic CB receptor agonistNew psychoactive substance
Molar mass
338.40 g/mol

Updated on

In plain terms

5F-SDB-006 is a molecule made entirely in a laboratory: it does not exist in hemp and has nothing to do with CBD. It belongs to the synthetic cannabinoids, products sprayed onto dried leaves then sold as smoking mixtures. No human data make it possible to describe its real effects or risks.

Receptors and activity

Target network

CB1AgonistEC50 = 1.5 µM · humanBRET for Gi1 protein engagement by hCB1 expressed in HEK293 cells, at 16 min
  • Activates

The lower the cited value, the closer the target sits to 5F-SDB-006: one ring per factor of 100. A target with no measured value stays on the edge.

Where these targets live

Where each target has been found in humans, according to the cited studies. The map shows the target, not an effect of 5F-SDB-006.

Brain, side view
Body, front view
Blood

CB1CB1 found in 7 regions of the body

  1. Basal gangliadenseMost dense in basal ganglia outflow nuclei1
  2. CerebellumdenseVery dense in the cerebellum1
  3. HippocampusdenseVery high concentrations in the hippocampus2
  4. AmygdaladenseHigh concentrations in the amygdala2
  5. CortexpresentPresent throughout the neocortex2
  6. Adipose tissuepresentExpressed in adipose tissue3
  7. GutpresentColonic epithelium, smooth muscle and plexus4

Map sources

  1. Herkenham M et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A, 1990 (new tab)
  2. Glass M et al. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience, 1997 (new tab)
  3. Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes, 2005 (new tab)
  4. Wright K et al. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology, 2005 (new tab)

Cited values

  1. CB1AgonistEC50 = 1.5 µM · human31 out of 100

    Yano et al. 2023, table 1 (BRET, HEK293) (new tab) · BRET for Gi1 protein engagement by hCB1 expressed in HEK293 cells, at 16 min

Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

Pharmacology

5F-SDB-006 is a cannabinoid receptor agonist of the indole-3-carboxamide type, combining a benzyl head and a 5-fluoropentyl chain. The published work agrees on a modest affinity and potency: Ametovski and colleagues (2020) report, for the benzylic series to which it belongs, CB1 Ki values from 550 nM to more than 10 µM, far below the corresponding cumyl derivatives. Above all, Yano and colleagues (2023) measured its efficacy at CB1 directly in BRET: 5F-SDB-006 shows the lowest efficacy of all the 5F-pentylindoles tested (57.9 % of that of CP55940 for Gi1 engagement, 46.0 % for β-arrestin 2), whereas in this family a change of head (3,3-dimethylbutanoate, cumyl) can turn a low-efficacy molecule into a full agonist or even one above the reference. Nothing allows a consumer to tell one analogue from another in a plant mixture. Human data are entirely lacking for 5F-SDB-006.

Key sources.

History

Source
No natural origin: the molecule is found neither in cannabis nor in any other plant. It is a synthetic cannabinoid of the indole-3-carboxamide type, studied with other synthetic cannabinoids of the same family, many of which have been identified in forensic samples (Hess 2016).

Origin

Laboratory synthesis

No biosynthetic pathway: an entirely synthetic molecule, with no plant precursor and no known enzyme. It belongs to the chemistry of N-alkylated indole-3-carboxamides bearing a terminal fluoropentyl chain; manufacture is not described here.

Classification

Family, origin and source verification

Family

Synthetic CB receptor agonist › New psychoactive substance

Class

indole-3-carboxamide

Verification

Classification, sources and binding values checked on 20 October 2026; text read against its sources and Wikipedia.

Wikipedia (English)

5F-SDB-006 (new tab)

Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

References

  1. Yano et al., subtle structural modification of a synthetic agonist that considerably increases its efficacy at CB1 (BRET in HEK293: Gi1 engagement and beta-arrestin 2 recruitment; 5F-SDB-006 the least efficacious among the 5F-pentylindoles), 2023 (new tab)PMID 37847546
  2. Ametovski et al., ACS Chemical Neuroscience, 2020: stereochemical and conformational requirements at cannabinoid receptors for synthetic cannabinoids related to SDB-006, 5F-SDB-006, CUMYL-PICA and 5F-CUMYL-PICA (new tab)PMID 33054155
  3. Glatfelter et al., structure-activity relationships of 5F-MDMB-PICA and its 5F-pentylindole analogues (including 5F-SDB-006) in the mouse, 2022 (new tab)PMID 34802041
  4. Hess et al., Forensic Toxicology, 2016: pharmacological evaluation of synthetic cannabinoids identified as constituents of « spice » (CB1 and CB2 affinities, GPR18, GPR55) (new tab)PMID 27429655
  5. ANSM, consolidated list of substances classified as narcotics, updated 16 February 2026, annex IV: family of indole-3-carboxamide derivatives (SDB-006 named) (new tab)
  6. INCB, Green List of psychotropic substances under international control, 35th edition, 2024 (Schedule II: 5F-SDB-006 absent) (new tab)
  7. PubChem, 5F-SDB-006, CID 91936847 (new tab)

Identifiers

Names

IUPAC name
N-benzyl-1-(5-fluoropentyl)indole-3-carboxamide
Other names
5-fluoro-SDB-006 · N-benzyl-1-(5-fluoropentyl)-1H-indole-3-carboxamide · 1-(5-fluoropentyl)-N-(phenylmethyl)-1H-indole-3-carboxamide

Identifiers

Formula
C₂₁H₂₃FN₂O
CAS
1776086-02-2
PubChem CID
91936847(new tab)
InChIKey
VFLXAWVAWXHMFB-UHFFFAOYSA-N
SMILES
C1=CC=C(C=C1)CNC(=O)C2=CN(C3=CC=CC=C32)CCCCCF

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.