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From the plant

CBCVACannabichromevarinic acid

A propyl acid of cannabis, the acid form of cannabichromevarin (CBCV).

Unscheduled
Level of detail

C₂₀H₂₆O₄

CAS 64898-02-8

Family
PhytocannabinoidMinor
Origin
Plant, enzyme unknown
Molar mass
330.40 g/mol

Updated on

In plain terms

Cannabichromevarinic acid is the natural, unheated form of cannabichromevarin. In mice, in a model of heat-triggered seizures, it raised the triggering threshold, which its decarboxylated form did not. Its effects in humans have not been studied in the sources consulted.

Receptors and activity

    Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

    Measured effects

    Not characterised. No placebo-controlled human trial has measured the effects of CBCVA, so no level is shown.

    Levels computed from placebo-controlled human trials: difference from placebo on 100, at the dose and route stated. Read the method

    Pharmacology

    Cannabichromevarinic acid (CBCVA) is the acid form of CBCV and the propyl-chain member of the cannabichromene series. It was isolated in 1977 by Shoyama and colleagues from the Thai cannabis "Meao variant", with three other propyl acids. Its formation by CBCA synthase is presumed but not demonstrated, and no affinity for the CB1 or CB2 receptors has been published. In Scn1a+/- mice, a model of Dravet syndrome, CBCVA significantly raised the thermal threshold for generalised tonic-clonic seizures, as did CBC and CBCA but not CBCV (Anderson et al. 2021). These results are from animals only.

    Key sources.

    History

    Source
    Cannabis sativa L.: present in acid form in the plant, isolated from the Thai cannabis "Meao variant" (Shoyama et al. 1977). The enzyme that forms it has not been characterised in the sources consulted.

    Biosynthetic pathway

    Divarinolic acid, the propyl homologue of olivetolic acid, condenses with geranyl pyrophosphate to form cannabigerovarinic acid (CBGVA). Cyclisation of CBGVA into CBCVA by CBCA synthase is presumed, by analogy with the pentyl series, but has not been demonstrated in the sources consulted. Like the other cannabinoid acids, CBCVA decarboxylates into CBCV under heat, time or light.

    Classification

    Family, origin and source verification

    Family

    Phytocannabinoid › Minor

    Presence in the plant

    Present in fresh plant material; enzyme not characterised

    Chemistry

    Type CBC · C3 side chain · acid form

    Verification

    Every fact on this entry was checked against its primary sources on 20 October 2026.

    Wikipedia (English)

    No dedicated article.

    References

    1. Shoyama Y. et al. 1977, Chem Pharm Bull 25:2306-2311: isolation and structures of four propyl-chain cannabinoid acids (new tab)DOI 10.1248/cpb.25.2306
    2. Radwan M.M. et al. 2021, Molecules 26:2774: inventory of 125 cannabinoids (CBCVA; THCVA reported in 1973) (new tab)PMID 34066753
    3. Anderson L.L. et al. 2021, ACS Chem Neurosci 12:330-339: CBC series (CBC, CBCA, CBCV, CBCVA) in a mouse model of Dravet syndrome (new tab)PMID 33395525
    4. GSRS UNII DMV4K7ENG6: cannabichromevarinic acid, CAS 64898-02-8 (new tab)
    5. PubChem CID 11110322: cannabichromevarinic acid (identifiers) (new tab)

    Identifiers

    Names

    Common name
    Cannabichromevarinic acid
    IUPAC name
    5-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-7-propylchromene-6-carboxylic acid
    Other names
    CBCVA

    Identifiers

    Formula
    C₂₀H₂₆O₄
    CAS
    64898-02-8
    PubChem CID
    11110322(new tab)
    InChIKey
    OIVPAQDCMDYIIL-UHFFFAOYSA-N
    SMILES
    CCCC1=CC2=C(C=CC(O2)(C)CCC=C(C)C)C(=C1C(=O)O)O

    Machine-readable entry (JSON)

    LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.