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From the plant

CBCVCannabichromevarin

The propyl homologue of cannabichromene, isolated from Thai cannabis in 1975.

Unscheduled
Level of detail

C₁₉H₂₆O₂

CAS 57130-04-8

Family
PhytocannabinoidMinor
Origin
Decarboxylation
Molar mass
286.40 g/mol

Updated on

In plain terms

Cannabichromevarin is the "short" version of cannabichromene: its side chain has three carbons instead of five. Present in very small amounts in some varieties, it remains little studied; its effects in humans have not been studied in the sources consulted.

Receptors and activity

    Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

    Measured effects

    Not characterised. No placebo-controlled human trial has measured the effects of CBCV, so no level is shown.

    Levels computed from placebo-controlled human trials: difference from placebo on 100, at the dose and route stated. Read the method

    Pharmacology

    Cannabichromevarin (CBCV) is the propyl-chain homologue of cannabichromene, isolated in 1975 by Shoyama and colleagues from the Thai cannabis "Meao variant", together with cannabigerovarin. It forms by decarboxylation of its acid, CBCVA; formation of that acid by CBCA synthase is presumed but not demonstrated. Its own pharmacology remains very poorly documented: no measured affinity for the CB1 or CB2 receptors has been published. In mice, CBCV was rapidly absorbed and penetrated the brain but, unlike CBC, CBCA and CBCVA tested under the same conditions, it did not raise the seizure threshold in a mouse model of Dravet syndrome (Anderson et al. 2021).

    Key sources.

    History

    Source
    Cannabis sativa L.: present in the plant, formed by non-enzymatic decarboxylation of its acid, CBCVA. (+)-CBCV was isolated from a Thai "Meao variant" cannabis; a racemic (±) CBCV has also been identified by gas chromatography coupled with mass spectrometry (Radwan et al. 2021).

    Biosynthetic pathway

    CBCV belongs to the propyl-chain series, which starts from divarinolic acid instead of olivetolic acid: condensation with geranyl pyrophosphate gives cannabigerovarinic acid (CBGVA). Conversion of CBGVA into cannabichromevarinic acid (CBCVA) by CBCA synthase is presumed, by analogy with the pentyl series, but has not been demonstrated in the sources consulted. Decarboxylation of CBCVA, under heat or ageing, gives CBCV.

    Classification

    Family, origin and source verification

    Family

    Phytocannabinoid › Minor

    Presence in the plant

    Neutral form: decarboxylation of a plant acid

    Chemistry

    Type CBC · C3 side chain · neutral form

    Verification

    Every fact on this entry was checked against its primary sources on 20 October 2026.

    Wikipedia (English)

    Cannabichromevarin (new tab)

    Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

    References

    1. Shoyama Y. et al. 1975, Chem Pharm Bull 23:1894-1895: cannabichromevarin and cannabigerovarin, two new propyl homologues (new tab)DOI 10.1248/cpb.23.1894
    2. Radwan M.M. et al. 2021, Molecules 26:2774: inventory of 125 cannabinoids (±CBCV and (+)-CBCV) (new tab)PMID 34066753
    3. Anderson L.L. et al. 2021, ACS Chem Neurosci 12:330-339: CBC, related phytocannabinoids and 5-fluoro-CBC in a mouse model of Dravet syndrome (new tab)PMID 33395525
    4. Brighenti V. et al. 2024, Anal Bioanal Chem 416:4555-4569: HPLC of impurities in natural and synthetic CBD (new tab)PMID 38940871
    5. ChEBI CHEBI:228766: cannabichromevarin (new tab)

    Identifiers

    Names

    Common name
    Cannabichromevarin
    IUPAC name
    2-methyl-2-(4-methylpent-3-enyl)-7-propylchromen-5-ol
    Other names
    CBCV · Cannabivarichromene

    Identifiers

    Formula
    C₁₉H₂₆O₂
    CAS
    57130-04-8
    PubChem CID
    6451726(new tab)
    ChEBI
    CHEBI:228766(new tab)
    InChIKey
    AAXZFUQLLRMVOG-UHFFFAOYSA-N
    SMILES
    CCCC1=CC(=C2C=CC(OC2=C1)(C)CCC=C(C)C)O

    Machine-readable entry (JSON)

    LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.