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From the plant

CBD-C1Cannabidiorcol

The methyl (C1) homologue of CBD, reported in traces: it activates the TRPV2 channel in the laboratory.

Unscheduled
Level of detail

C₁₇H₂₂O₂

CAS 35482-50-9

Family
PhytocannabinoidMinor
Origin
Tentative identification
Molar mass
258.35 g/mol

Updated on

In plain terms

Cannabidiorcol is a close relative of CBD whose side chain has only one carbon atom instead of five. It was reported in hashish in 1972, by an identification that remains tentative. In the laboratory it activates the cellular channel TRPV2; its effects in humans have not been studied.

Receptors and activity

Target network

  • Activates

The lower the cited value, the closer the target sits to CBD-C1: one ring per factor of 100. A target with no measured value stays on the edge.

Cited values

  1. TRPV2Agonistno measured value cited
Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

Measured effects

Not characterised. No placebo-controlled human trial has measured the effects of CBD-C1, so no level is shown.

Levels computed from placebo-controlled human trials: difference from placebo on 100, at the dose and route stated. Read the method

Pharmacology

Cannabidiorcol (CBD-C1, also referenced as O-1821) is the methyl-chain homologue of cannabidiol: the same resorcinol skeleton linked to a p-menthadiene ring, with (1R,6R) configuration, but a single side-chain carbon instead of five. Vree and colleagues reported it in 1972 in hashish by gas chromatography coupled with mass spectrometry; this identification remains tentative, the molecule not having been isolated from the plant in the sources consulted. No affinity constant for CB1 or CB2 was found. In the screen by Qin et al. (J Neurosci, 2008), the compound activated rat TRPV2 expressed in HEK293 cells: at 100 µM, the calcium response reached 93% of that of the reference agonist 2-APB, with no EC50 determined; the responses at TRPA1 (7%) and TRPV1 (15%) were weak. Used as a TRPV2 agonist, O-1821 has been studied in mice: in a collagen-induced arthritis model, 20 to 30 mg/kg per day was associated with milder clinical disease than in controls (Laragione et al. 2023). In cultured oesophageal squamous cell carcinoma cells, by contrast, activation of TRPV2 by O-1821 (20 µM) promoted cancerous behaviours (Huang et al. 2022). CBD-C1 is one of the 13 cannabinoids of an HPLC-MS/MS method validated in oral fluid (Lin et al. 2022). No pharmacokinetic, metabolism or toxicology data in humans have been published.

Key sources.

History

Source
Cannabis sativa L.: tentative identification only. Cannabidiorcol was detected by gas chromatography coupled with mass spectrometry in a hexane extract of Lebanese hashish (Vree et al. 1972, according to Radwan et al. 2021), without isolation or confirmation against a reference standard in the plant. Origin not established.

Biosynthetic pathway

No biosynthetic pathway has been demonstrated for this methyl-chain (C1) homologue. Neither the corresponding acid nor an enzyme specific to the C1 series was found in the sources consulted; any sequence modelled on that of cannabidiol would remain a hypothesis.

Classification

Family, origin and source verification

Family

Phytocannabinoid › Minor

Presence in the plant

Tentative identification, never isolated

Chemistry

Type CBD · C1 side chain · neutral form

Verification

Every fact on this entry was checked against its primary sources on 20 October 2026.

Wikipedia (English)

Cannabidiorcol (new tab)

Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

References

  1. Vree T. B. et al., identification in hashish of the methyl side-chain analogues of THC, CBD and CBN, J Pharm Pharmacol 1972, 24:7-12 (new tab)PMID 4401327
  2. Qin N. et al., TRPV2 activation by cannabinoids (O-1821, table 1), J Neurosci 2008 (new tab)PMID 18550765
  3. Laragione T. et al., TRPV2 agonist O1821 and etanercept in collagen-induced arthritis in the mouse, Clin Exp Immunol 2023 (new tab)PMID 36571199
  4. Huang R. et al., TRPV2 activation (heat or O1821) promotes tumorigenesis of oesophageal squamous cell carcinoma, Br J Cancer 2022 (new tab)PMID 35896815
  5. Lin L. et al., HPLC-MS/MS assay of 13 cannabinoids, including CBD-C1, in saliva, J Anal Toxicol 2022 (new tab)PMID 33270860
  6. PubChem CID 16657068 and GSRS UNII 259WR5E2RF: cannabidiorcol (1R,6R), CAS 35482-50-9 (new tab)
  7. ANSM, consolidated list of substances classified as narcotics, updated 26/06/2026 (new tab)

Identifiers

Names

Common name
Cannabidiorcol
IUPAC name
5-methyl-2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene-1,3-diol
Other names
CBDO · CBD-C1 · O-1821

Identifiers

Formula
C₁₇H₂₂O₂
CAS
35482-50-9
PubChem CID
16657068(new tab)
InChIKey
GKVOVXWEBSQJPA-UONOGXRCSA-N
SMILES
CC1=C[C@H]([C@@H](CC1)C(=C)C)C2=C(C=C(C=C2O)C)O

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.