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From the plant

CBDHCannabidihexol

Hexyl homologue of CBD, isolated in 2020 from the medicinal variety FM2, present in trace amounts.

Unscheduled
Level of detail

C₂₂H₃₂O₂

CID 140883953

Family
PhytocannabinoidMinor
Origin
Decarboxylation
Molar mass
328.50 g/mol

Updated on

In plain terms

Cannabidihexol is a CBD whose side chain has one carbon more. Discovered in 2020 in very small amounts in an Italian medicinal cannabis variety, it has only been studied in mice, in a single laboratory test. Its effects in humans are unknown.

Receptors and activity

    Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

    Measured effects

    Not characterised. No placebo-controlled human trial has measured the effects of CBDH, so no level is shown.

    Levels computed from placebo-controlled human trials: difference from placebo on 100, at the dose and route stated. Read the method

    Pharmacology

    Cannabidihexol (CBDH) is the hexyl-chain (C6) homologue of cannabidiol, described in 2020 by Linciano, Citti, Cannazza et al. in the Italian medicinal cannabis variety FM2. Identified by UHPLC-HRMS by comparison with a synthetic standard, it was isolated in the form of its acid, CBDHA, and then decarboxylated by heat (about 0.3 mg obtained); its content was estimated at 27 µg/g, versus 56 mg/g for CBD. In mice, CBDH reduced the late phase of the response in the formalin test at 1 and 2 mg/kg intraperitoneally, but not at 3 or 5 mg/kg. No affinity for CB1 or CB2 has been measured. The same study identified Δ9-THCH in the extract (about 7 µg/g) but could not isolate it, because of its very low abundance. Together with CBDP, CBDH serves as a marker of a natural origin of CBD (Brighenti et al. 2024).

    Key sources.

    History

    Source
    Cannabis sativa L.: a constituent present in trace amounts in the Italian medicinal variety FM2 (about 27 µg/g), where its acid, CBDHA, was detected in the unheated extract (Linciano et al. 2020). The origin of the hexyl chain is not established.

    Biosynthetic pathway

    CBDH is the neutral form produced by decarboxylation of its acid, CBDHA, detected in the unheated extract of the FM2 variety; Linciano et al. (2020) obtained CBDH by heating isolated CBDHA fractions. The origin of the hexyl chain remains unknown: homologues with an even number of carbons had until then been assumed to be artefacts of fungal ω-oxidation, and the authors leave the question open while regarding their presence in the plant as certain.

    Classification

    Family, origin and source verification

    Family

    Phytocannabinoid › Minor

    Presence in the plant

    Neutral form: decarboxylation of a plant acid

    Chemistry

    Type CBD · C6 side chain · neutral form

    Verification

    Every fact on this entry was checked against its primary sources on 20 October 2026.

    Wikipedia (English)

    No dedicated article.

    References

    1. Linciano et al. 2020, Sci Rep 10:22019 (identification and isolation of cannabidihexol; formalin test in mice) (new tab)PMID 33328530
    2. Brighenti et al. 2024, Anal Bioanal Chem 416:4555-4569 (CBDH and CBDP, markers of naturally derived CBD) (new tab)PMID 38940871
    3. PubChem CID 140883953: cannabidihexol (identifiers) (new tab)
    4. ANSM, consolidated list of narcotics (26/06/2026) (new tab)

    Identifiers

    Names

    Common name
    Cannabidihexol
    IUPAC name
    5-hexyl-2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene-1,3-diol
    Other names
    CBDH · CBD-C6 · CBD hexylique

    Identifiers

    Formula
    C₂₂H₃₂O₂
    PubChem CID
    140883953(new tab)
    InChIKey
    HAKUWGCTBUVNJQ-RBUKOAKNSA-N
    SMILES
    CCCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O

    Machine-readable entry (JSON)

    LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.