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From the plant

CBFCannabifuran

A fully aromatic furanoid cannabinoid described in hashish, pharmacology not measured.

Unscheduled
Level of detail

C₂₁H₂₆O₂

CAS 56154-58-6

Family
PhytocannabinoidMinor
Origin
Origin not established
Molar mass
310.40 g/mol

Updated on

In plain terms

Cannabifuran is a rare cannabinoid described in hashish in 1975. Its framework is fully aromatic and its central ring is a furan, where THC has a pyran. No measurement of its action on the body has been published.

Receptors and activity

    Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

    Measured effects

    Not characterised. No placebo-controlled human trial has measured the effects of CBF, so no level is shown.

    Levels computed from placebo-controlled human trials: difference from placebo on 100, at the dose and route stated. Read the method

    Pharmacology

    Cannabifuran belongs to the furanoid family of cannabinoids, in which a furan ring replaces the pyran ring of THC. Friedrich-Fiechtl and Spiteller described it in 1975 in an extract of Afghan hashish, together with dehydrocannabifuran, OTHC and cannabichromanone; its origin is not established. Its dibenzofuran nucleus is fully aromatic, unlike that of cannabielsoin. No affinity for CB1 or CB2 has been measured. The review by Anand and colleagues (2024) notes that no psychoactivity has been reported for furanoid cannabinoids, without any measurement specific to cannabifuran. The compound also carries a lesson in method: ElSohly and Slade (2005) report that a cannabinoid published in 1972 as cannabinodiol by Van Ginneken was in fact cannabifuran, which makes references to cannabinodiol based on that work suspect.

    Key sources.

    History

    Source
    A minor constituent described in hashish (resin); origin not established.

    Biosynthetic pathway

    No enzyme or formation mechanism has been established: the inventories report its isolation without assigning it an origin. Its fully aromatic dibenzofuran nucleus places it in the furanoid family; Dennis and colleagues (2022) prepared the cannabifuran class in the laboratory from cannabidiol.

    Classification

    Family, origin and source verification

    Family

    Phytocannabinoid › Minor

    Presence in the plant

    Present in the plant; origin not established

    Chemistry

    Miscellaneous · C5 side chain · neutral form

    Verification

    Every fact on this entry was checked against its primary sources on 20 October 2026.

    Wikipedia (English)

    No dedicated article.

    References

    1. Friedrich-Fiechtl & Spiteller 1975, Tetrahedron 31:479-487: « Neue Cannabinoide 1 » (isolation from Afghan hashish) (new tab)DOI 10.1016/0040-4020(75)85016-2
    2. ElSohly & Slade 2005, Life Sci: critical inventory (reassignment of Van Ginneken's « cannabinodiol » to cannabifuran) (new tab)PMID 16199061
    3. Anand et al. 2024, Eur J Med Chem: chemistry and pharmacology of furan cannabinoids (new tab)PMID 38417219
    4. Dennis et al. 2022, J Org Chem: synthesis of the cannabimovone and cannabifuran classes; BV2 microglia (new tab)PMID 35476908
    5. Radwan et al. 2021, Molecules: inventory of cannabis cannabinoids (« miscellaneous » class) (new tab)PMID 34066753
    6. PubChem CID 9966466: cannabifuran (new tab)

    Identifiers

    Names

    Common name
    Cannabifuran
    IUPAC name
    6-methyl-3-pentyl-9-propan-2-yldibenzofuran-1-ol
    Other names
    CBF-C5

    Identifiers

    Formula
    C₂₁H₂₆O₂
    CAS
    56154-58-6
    PubChem CID
    9966466(new tab)
    InChIKey
    VNGQMWZHHNCMLQ-UHFFFAOYSA-N
    SMILES
    CCCCCC1=CC(=C2C(=C1)OC3=C(C=CC(=C23)C(C)C)C)O

    Machine-readable entry (JSON)

    LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.