CUMYL-BC-HPMEGACLONE-221NBMEGACLONE

CUMYL-BC-HPMEGACLONE-221, also called NBMEGACLONE, is a synthetic cannabinoid of the gamma-carbolinone class, bearing a cumyl group and a norbornylmethyl substituent. In the study by Pulver et al. (2023), the six derivatives compared are full CB1 agonists, and the three norbornylmethyl derivatives have affinities between 0.25 and 1.87 nM, although the value specific to this compound is not given in the abstract consulted. Human metabolism was described from 4 authentic urine samples, which yielded 9 phase I metabolites and two markers of consumption (Giorgetti et al., 2025). In the sources consulted, no clinical study, no human toxicology data and no pharmacokinetic data appear. Its French legal status remains evolving: it is not named in the ANSM list, and the generic definition that could cover it does not settle its case.

Source

Entirely synthetic molecule, absent from the plant. It has been identified in herbal blends onto which it was applied, and belongs to a group of three related compounds carrying a norbornylmethyl substituent (Pulver et al., 2021).

No known biosynthetic pathway: a chemically synthesised molecule, with no known natural equivalent, belonging to the class of cumylated gamma-carbolinones.

European Union

No harmonised European Union control measure was found for this molecule in the sources consulted. It does not appear in the schedules of the 1971 Convention as reproduced in the INCB Green List 2026. Control therefore falls under the national legislation of the Member States, which are not detailed here.

France

This compound is not named in the consolidated list of substances classed as narcotics published by ANSM, updated 16 February 2026. The generic text covering “3-carboxamide indole derivatives” could apply to it: the nitrogen of the carboxamide bridge is part of a ring, a condition met here. However, the condition on the substituent of the indole nitrogen, “cycloalkylmethyl” or equivalent, is not settled by the text for a bridged bicyclic substituent such as norbornylmethyl. As this cannot be decided with certainty, the status is treated as evolving. The neighbouring compound CUMYL-CH-MEGACLONE, with a cyclohexylmethyl ring, is by contrast named by a decision of 22 May 2024.

Sources: EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA. Our method.

1. 1Pulver et coll., pharmacologie, prévalence en Allemagne et données analytiques des agonistes cannabinoïdes de synthèse à chaîne cyclobutylméthyle et norbornylméthyle, Drug Testing and Analysis, 2023 (new tab)PMID 36541839
2. 2Giorgetti et coll., métabolisme de phase I humain de trois agonistes cumylés (Cumyl-CBMEGACLONE, Cumyl-NBMEGACLONE, Cumyl-NBMINACA), Drug Testing and Analysis, 2025 (new tab)PMID 39218806
3. 3Pulver et coll., jeu de données spectrales pour l'identification de trois cannabimimétiques de synthèse à chaîne norbornylméthyle, Data in Brief, 2021 (new tab)PMID 34988267
4. 4ANSM, Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (new tab)
5. 5INCB, Green List 2026 (substances des tableaux de la Convention de 1971) (new tab)
6. 6PubChem, CID 163190698 (new tab)

SMILES

CC(C)(c1ccccc1)N1C=Cc2n(CC3CC4CCC3C4)c3ccccc3c2C1=O

InChIKey

VFBNNQOHBYEVLU-UHFFFAOYSA-N

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.