FAB-144
Synthetic cannabinoid with an indazole core, no published human data, covered by a generic definition in France.
C₂₀H₂₇FN₂O
Harm-reduction warning
No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.
Data sheet
Names
- IUPAC name
- [1-(5-fluoropentyl)indazol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone
Identifiers
- Formula
- C₂₀H₂₇FN₂O
- Molar mass
- 330.40 g/mol
- PubChem CID
- 102135350(new tab)
- InChIKey
- LVJQJRUAYXVEGN-UHFFFAOYSA-N
Class
- Family
- Synthetic cannabinoid (SCRA)
Updated on
Receptors and activity
- CB1Agonist80 out of 100
Ki 17,5 ± 1,1 nM (Hess et coll., 2016, tableau 1) ; affinité légèrement supérieure à celle de l'UR-144 dans le même article
- CB2Agonist95 out of 100
Ki 0,450 ± 0,111 nM (Hess et coll., 2016, tableau 1) ; affinité légèrement supérieure à celle de l'UR-144, avec la préférence pour CB2 partagée par les dérivés tétraméthylcyclopropyle du groupe
Subjective signature
- Calm
- 6 out of 100
- Relaxation of body and mind; reduced mental noise without marked drowsiness.
- Clarity
- 3 out of 100
- Sustained attention and clear thinking; functional lucidity, not euphoria.
- High
- 8 out of 100
- Euphoria and sensory intensity; altered perception of time and space.
- Appetite
- 4 out of 100
- Stimulation of hunger and of taste appreciation (the “munchies” effect).
- Sleep
- 5 out of 100
- Sedative effect: aids sleep onset and the continuity of deep sleep.
Pharmacology
FAB-144 is an indazol-3-yl methanone, the indazole analogue of XLR-11 and the 5-fluoropentyl analogue of UR-144, and an agonist of the CB1 and CB2 cannabinoid receptors. Hess et al. (2016) describe an affinity slightly higher than that of UR-144 at both receptors, almost identical to that of XLR-11; the numerical values are given in their Table 1. The authors do not place it among the agonists with lower efficacy than THC. No human study, and no pharmacokinetic, metabolic or toxicological data specific to this molecule, has been identified, and no therapeutic use is established.
Key sources.
- Hess C. et coll., Forensic Toxicology, 2016 : évaluation pharmacologique des cannabinoïdes de synthèse identifiés dans le spice (new tab)PMID 27429655
- ANSM · Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (rubrique indazol-3-yl méthanone) (new tab)
- OICS · Liste verte des substances psychotropes sous contrôle international, édition 2026 (new tab)
- PubChem · CID 102135350, FAB-144 (new tab)
History
- Source
- Entirely synthetic molecule, absent from cannabis. It is the indazole analogue of XLR-11 and the 5-fluoropentyl analogue of UR-144 (Hess et al., 2016): the indole of the skeleton is replaced by an indazole.
Origin (pharmaceutical research → illicit market)
No biosynthetic pathway: FAB-144 is a synthetic compound, unrelated to the terpenophenols of hemp. It belongs to the class of indazole ketones, obtained by organic synthesis, described here by chemical class only.
Legal framework
- European Union
No harmonised European Union control measure has been identified for this molecule in the sources consulted: control falls under national legislation.
- France
FAB-144 is not named in the consolidated ANSM list of 16 February 2026, but it falls under the generic definition of indazol-3-yl methanones, in the families block of the list (order of 22 February 1990, as amended). The nitrogen at position 1 of the indazole ring carries a haloalkyl substituent, 5-fluoropentyl, and the methanone bridge carbon carries a cyclopropyl group, here tetramethylated, which the definition allows whether substituted or not. Both conditions being met, the molecule is classed as a narcotic. Use, possession, transfer and importation are prohibited.
Sources: EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA. Our method.
References
- Hess C. et coll., Forensic Toxicology, 2016 : évaluation pharmacologique des cannabinoïdes de synthèse identifiés dans le spice (new tab)PMID 27429655
- ANSM · Liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (rubrique indazol-3-yl méthanone) (new tab)
- OICS · Liste verte des substances psychotropes sous contrôle international, édition 2026 (new tab)
- PubChem · CID 102135350, FAB-144 (new tab)
Structured data
- SMILES
- CC1(C)C(C(=O)c2nn(CCCCCF)c3ccccc23)C1(C)C
- InChIKey
- LVJQJRUAYXVEGN-UHFFFAOYSA-N
LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.