JWH-032
Research naphthoylpyrrole with no measurable CB1 binding up to 10 µM, classed as a narcotic in France under a family clause.
C₁₈H₁₇NO
Harm-reduction warning
No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.
Data sheet
Names
- IUPAC name
- naphthalen-1-yl-(1-propylpyrrol-3-yl)methanone
- Other names
- 1-Naphthyl(1-propyl-1H-pyrrol-3-yl)methanone
Identifiers
- Formula
- C₁₈H₁₇NO
- Molar mass
- 263.30 g/mol
- PubChem CID
- 10084127(new tab)
- InChIKey
- ANVCANCAZRKUGF-UHFFFAOYSA-N
Class
- Family
- Synthetic cannabinoid (SCRA)
Updated on
Receptors and activity
- CB1Modulator5 out of 100
Ki > 10 000 nM (Wiley et coll., 2014 ; BindingDB, CB1 de rat)
Subjective signature
- Calm
- 5 out of 100
- Relaxation of body and mind; reduced mental noise without marked drowsiness.
- Clarity
- 5 out of 100
- Sustained attention and clear thinking; functional lucidity, not euphoria.
- High
- 5 out of 100
- Euphoria and sensory intensity; altered perception of time and space.
- Appetite
- 5 out of 100
- Stimulation of hunger and of taste appreciation (the “munchies” effect).
- Sleep
- 5 out of 100
- Sedative effect: aids sleep onset and the continuity of deep sleep.
Pharmacology
JWH-032 is an N-propyl naphthoylpyrrole, a research compound from the program of John W. Huffman at Clemson University. It differs from JWH-030 by a chain two carbons shorter than the pentyl chain. In the 2014 review by Wiley et al., naphthoylpyrroles with an N-alkyl chain from methyl to propyl do not bind the CB1 receptor (Ki above 10 000 nM), whereas JWH-030 reaches a Ki of 87 nM. CB2 affinity and functional efficacy are not documented in the sources consulted, and no human data were found.
Key sources.
- Wiley et coll., relations structure-activité et effets in vivo des cannabinoïdes de synthèse (revue), Life Sci 2014 (new tab)PMID 24071522
- Wiley et coll., relations structure-activité des cannabinoïdes dérivés de l'indole et du pyrrole, J Pharmacol Exp Ther 1998 (new tab)PMID 9618400
- Pertwee et coll., caractérisation de trois agonistes cannabinoïdes nouveaux sur le canal déférent de souris (dont la 1-pentyl-3-(1-naphtoyl)pyrrole), Eur J Pharmacol 1995 (new tab)PMID 8666005
- BindingDB, entrée BDBM85802 (JWH-032), Ki sur le CB1 de rat, données du programme PDSP (new tab)
- PubChem, CID 10084127 (JWH-032), identifiants et synonymes (new tab)
- ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (annexe IV, famille des naphtoylpyrroles) (new tab)
History
- Source
- Synthetic molecule, described as a research compound. No source consulted reports it as produced by a plant or another living organism.
Origin (pharmaceutical research → illicit market)
No known biosynthetic pathway: a synthetic organic molecule from the acylpyrrole chemical family. No manufacturing process is described here.
Legal framework
- European Union
No harmonised European Union control measure was found in the sources consulted for this compound; control currently rests with national legislation.
- France
Classed as a narcotic in France by a family clause, not by name: JWH-032 is not named in the ANSM consolidated list of 16 February 2026. It meets the conditions of the naphthoylpyrroles definition in Annex IV of the order of 22 February 1990, block "Ainsi que toute molécule appartenant à la famille des": a pyrrol-3-yl (1-naphthyl) methanone core, an alkyl substituent on the pyrrole nitrogen (here propyl), with the pyrrole and naphthyl rings substituted or not (here, they are not).
Sources: EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA. Our method.
References
- Wiley et coll., relations structure-activité et effets in vivo des cannabinoïdes de synthèse (revue), Life Sci 2014 (new tab)PMID 24071522
- Wiley et coll., relations structure-activité des cannabinoïdes dérivés de l'indole et du pyrrole, J Pharmacol Exp Ther 1998 (new tab)PMID 9618400
- Pertwee et coll., caractérisation de trois agonistes cannabinoïdes nouveaux sur le canal déférent de souris (dont la 1-pentyl-3-(1-naphtoyl)pyrrole), Eur J Pharmacol 1995 (new tab)PMID 8666005
- BindingDB, entrée BDBM85802 (JWH-032), Ki sur le CB1 de rat, données du programme PDSP (new tab)
- PubChem, CID 10084127 (JWH-032), identifiants et synonymes (new tab)
- ANSM, liste consolidée des substances classées comme stupéfiants, mise à jour du 16 février 2026 (annexe IV, famille des naphtoylpyrroles) (new tab)
Structured data
- SMILES
- CCCN1C=CC(=C1)C(=O)C2=CC=CC3=CC=CC=C32
- InChIKey
- ANVCANCAZRKUGF-UHFFFAOYSA-N
LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.