CBCCannabichromene

2-méthyl-2-(4-méthylpent-3-én-1-yl)-7-pentyl-2H-chromén-5-ol

Aliases.Cannabichromène

Acts on the TRP channels - which explains its analgesic potential in synergy with CBD.

Updated on 1 May 2026

Level of detail

Identifiers

Formula: C₂₁H₃₀O₂
Molar mass: 314.46 g·mol⁻¹
CAS: 20675-51-8
PubChem CID: 30219
First described: 1966
Origin: Plant
InChIKey: UVOLYTDXHDXWJU-UHFFFAOYSA-N

In plain terms

CBC does not get you high. It acts mainly on the pain and heat channels (TRP), which explains its analgesic effect in synergy with CBD. Present only in trace amounts, and one of the major contributors to the "entourage effect".

Receptors and activity

TRPA1
agoniste très puissantAgonist
TRPV1
agonisteAgonist
CB2
agoniste partiel faiblePartial agonist

Agonist
Partial agonist
Antagonist
Modulator
Inverse agonist

Hover over a row for the precise value (Ki, EC50…)

Subjective signature

Hover over an axis to read its definition.

Calm
55
Clarity
50
Sleep
35
Appetite
30
High
45

Editorial estimate, not clinical.

Pharmacology

Under-represented in commercial chemotypes but documented as one of the major contributors to the entourage effect. CBC acts mainly through the TRP ion channels - TRPA1 (its main target, and among the most potent phytogenic agonists known) and TRPV1 - which are involved in the perception of pain and heat. It is this TRP profile that explains its analgesic potential in synergy with CBD. There are interesting preclinical studies on hippocampal neurogenesis (Shinjyo & Di Marzo 2013, PMID 23892791) - a mouse model in which CBC promotes the proliferation of adult neural stem cells - and on mood. Its commercial rarity stems from the fact that its acid form (CBCA) degrades rapidly in light, requiring drying in darkness and impeccable packaging in order to preserve the percentages stated on the batch sheet.

Key sources.