THCVTetrahydrocannabivarin

Aliases.Tetrahydrocannabivarine · THC-V

Blocks CB1 at low dose and suppresses appetite - the exact opposite of THC.

Updated on 1 May 2026

Level of detail

Identifiers

Formula: C₁₉H₂₆O₂
CAS: 31262-37-0
PubChem CID: 93147
First described: 1973
Origin: Plant

In plain terms

THCV is the opposite of THC at low dose: it blocks CB1, so it suppresses appetite instead of stimulating it. At high dose, it becomes slightly intoxicating itself. A "daytime" profile, studied in diabetes and nicotine dependence.

Receptors and activity

CB1 (faible dose)
Antagonist
CB1 (forte dose)
Partial agonist
CB2
Agonist

Agonist
Partial agonist
Antagonist
Modulator
Inverse agonist

Hover over a row for the precise value (Ki, EC50…)

Subjective signature

Hover over an axis to read its definition.

Calm
30
Clarity
80
Sleep
15
Appetite
5
High
70

Editorial estimate, not clinical.

Pharmacology

A propyl variant of THC, in which the pentyl chain is shortened to a propyl one (three carbons instead of five). This structural modification partly reverses the effect on appetite: at low dose, THCV blocks CB1 and suppresses the sensation of hunger, the exact opposite of THC. At high dose, it becomes slightly psychotropic itself. Found mainly in chemotypes of African origin (South Africa, Malawi). Research is under way into its interest in glycaemic regulation (open trials on insulin resistance) and nicotine dependence. For Phytogrammes, it serves as a strategic complement in certain daytime profiles.