CBGCannabigerol

2-[(2E)-3,7-diméthylocta-2,6-dién-1-yl]-5-pentylbenzène-1,3-diol

Aliases.Cannabigérol

The mother molecule: the precursor from which the plant builds THC, CBD and CBC.

Updated on 1 May 2026

Level of detail

Identifiers

Formula: C₂₁H₃₂O₂
Molar mass: 316.48 g·mol⁻¹
CAS: 25654-31-3
PubChem CID: 5315659
First described: 1964
Origin: Plant
InChIKey: QXACEHWTBCFNSA-SFQUDFHCSA-N

In plain terms

CBG is the molecule the plant starts from. Non-intoxicating, present in small amounts in most varieties, it is now grown for in its own right.

Receptors and activity

CB1
agoniste partiel faible · µM rangePartial agonist
CB2
agoniste partielPartial agonist
α2-adrénergique
EC50 0,2–72,8 nMAgonist
5-HT1A
KB = 51,9 nMAntagonist
TRPM8
antagonisteAntagonist
PPARγ
agonisteAgonist

Agonist
Partial agonist
Antagonist
Modulator
Inverse agonist

Hover over a row for the precise value (Ki, EC50…)

Subjective signature

Hover over an axis to read its definition.

Calm
60
Clarity
85
Sleep
25
Appetite
50
High
65

Editorial estimate, not clinical.

Pharmacology

Cannabigerol comes from the decarboxylation of CBGA, the acidic precursor that three synthases convert into THCA, CBDA or CBCA. It is therefore present in low concentration in mature plants, most of it having already been converted - which is why CBG-dominant varieties are harvested early or bred specifically. Its own pharmacology is distinct from CBD's: weak cannabinoid-receptor affinity, but documented α2-adrenergic and 5-HT1A activity.

Key sources.