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Synthetic

FUB-PB-22

A fluorobenzylated quinolinyl ester of indole-3-carboxylate, detected in 2014, classified as a narcotic in France.

Narcotic: named in schedule
Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

C₂₅H₁₇FN₂O₂

CAS 1800098-36-5

Family
Synthetic CB receptor agonistNew psychoactive substance
Molar mass
396.40 g/mol

Updated on

In plain terms

FUB-PB-22 is a synthetic cannabinoid made in a laboratory, detected in 2014 in herbal blends in Japan, Russia and Germany. It does not exist in hemp and has nothing to do with cannabidiol. It binds to the cannabinoid receptors with a measured affinity below 0.5 nM, and it is classified as a narcotic in France.

Receptors and activity

Target network

CB1AgonistKi = 0.4 nM · humancompetitive [3H]CP55,940 binding, CHO cell membranes
  • Activates

The lower the cited value, the closer the target sits to FUB-PB-22: one ring per factor of 100. A target with no measured value stays on the edge.

Where these targets live

Where each target has been found in humans, according to the cited studies. The map shows the target, not an effect of FUB-PB-22.

Brain, side view
Body, front view
Blood

CB1CB1 found in 7 regions of the body

  1. Basal gangliadenseMost dense in basal ganglia outflow nuclei1
  2. CerebellumdenseVery dense in the cerebellum1
  3. HippocampusdenseVery high concentrations in the hippocampus2
  4. AmygdaladenseHigh concentrations in the amygdala2
  5. CortexpresentPresent throughout the neocortex2
  6. Adipose tissuepresentExpressed in adipose tissue3
  7. GutpresentColonic epithelium, smooth muscle and plexus4

Map sources

  1. Herkenham M et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A, 1990 (new tab)
  2. Glass M et al. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience, 1997 (new tab)
  3. Engeli S et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes, 2005 (new tab)
  4. Wright K et al. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology, 2005 (new tab)

Cited values

  1. CB1AgonistKi = 0.4 nM · human90 out of 100

    Hess et al. 2016, Forensic Toxicol (new tab) · competitive [3H]CP55,940 binding, CHO cell membranes

  2. CB2AgonistKi = 0.5 nM · human89 out of 100

    Hess et al. 2016, Forensic Toxicol (new tab) · competitive [3H]CP55,940 binding, CHO cell membranes

Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

Pharmacology

FUB-PB-22 is one of the compounds that show the gap between control and knowledge for this generation of synthetic cannabinoids. Detected in 2014 together with FDU-PB-22 in herbal blends in Japan, Russia and Germany, it was quickly added to the scheduled-drug lists of those countries, although no human metabolism data were available to confirm intake (Diao et al. 2016). On human receptors, Hess et al. (2016) measure Ki values of 0.386 nM at CB1 and 0.478 nM at CB2. The study by Diao et al., in human hepatocytes and then in two authentic urine samples, identified seven metabolites for each of the two compounds, produced by ester hydrolysis followed by hydroxylation and glucuronidation; half-lives in human liver microsomes are 11.5 minutes for FUB-PB-22 and 12.4 minutes for FDU-PB-22. After ester hydrolysis, the two compounds give the same metabolite, fluorobenzylindole-3-carboxylic acid, so that a urinary marker does not distinguish the two parent substances; the authors recommend this metabolite and its hydroxylated form to document intake of FDU-PB-22 and/or FUB-PB-22. No controlled study in human beings was found.

Key sources.

History

Source
A wholly synthetic molecule, absent from hemp and from every living organism. It was detected in 2014 in herbal blends in Japan, Russia and Germany (Diao et al. 2016). None of this has anything to do with hemp or with cannabidiol products.

Origin

Laboratory synthesis

No known biosynthetic pathway: the molecule is produced by no plant and no living organism. It is entirely synthetic in origin and belongs to the chemical family of the quinolin-8-yl indole-3-carboxylates.

Classification

Family, origin and source verification

Family

Synthetic CB receptor agonist › New psychoactive substance

Class

indole-3-carboxylate

Verification

Classification, sources and binding values checked on 20 October 2026; text read against its sources and Wikipedia.

Wikipedia (English)

FUB-PB-22 (new tab)

Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

References

  1. Diao X, Scheidweiler KB, Wohlfarth A, Pang S, Kronstrand R, Huestis MA. In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22. AAPS J. 2016;18(2):455-464 (new tab)PMID 26810398
  2. Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE. Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice. Forensic Toxicol. 2016;34:329-343 (new tab)PMID 27429655
  3. Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y. Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicol. 2013;31(2):223-240 (new tab)DOI 10.1007/s11419-013-0182-9
  4. Takeda A, Doi T, Asada A et al. The biological effects and thermal degradation of NPB-22, a synthetic cannabinoid. Forensic Toxicol. 2024;42(2):142-151 (indazole analogue: thermal degradation of the ester, products with no CB1 or CB2 activity) (new tab)PMID 38294576
  5. Council Framework Decision 2004/757/JHA, consolidated version of 12.01.2026 (annex: substances subject to Union control) (new tab)

Identifiers

Names

IUPAC name
quinolin-8-yl 1-[(4-fluorophenyl)methyl]indole-3-carboxylate
Other names
FUB-PB22

Identifiers

Formula
C₂₅H₁₇FN₂O₂
CAS
1800098-36-5
PubChem CID
91936864(new tab)
ChEBI
183979(new tab)
InChIKey
ROHVURVXAOMRJY-UHFFFAOYSA-N
SMILES
C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)F)C(=O)OC4=CC=CC5=C4N=CC=C5

Machine-readable entry (JSON)

LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.