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Derived from the plant

THCP-OTetrahydrocannabiphorol acetate

The acetic ester of Δ9-THCP, detected on the European market since 2023; no pharmacological data of its own.

FranceNarcotic: generic clauseInternationalStatus changing
Level of detail

Harm-reduction warning

No characterised human dose: animal / in vitro data only. Effect profile, safety margin and acute toxicity are not documented in human clinical practice. Extremely potent compound: severe effects, seizures and deaths reported in the literature.

C₂₅H₃₆O₃

CAS 2829292-82-0

Family
Semi-synthetic cannabinoidEster or prodrug
Molar mass
384.60 g/mol

Updated on

In plain terms

THCP-O is made in the laboratory: one starts from THCP, a cannabinoid present only at trace levels in cannabis, and adds an acetate group. It does not exist in the plant and appears only in market products, often at trace levels. No study describes its own effects in humans, and heating cannabinoid acetates can produce a toxic gas.

Receptors and activity

    Bar length follows the measured value (Ki, Kd, EC50 or IC50), on one scale shared by every entry, from 100 µM to 0.1 nM. A target with no cited value has no bar.

    Pharmacology

    THCP-O is the acetic ester of Δ9-THCP, formed on the phenol at position 1; cannabinoids acylated at the phenol do not occur naturally (EMCDDA 2023). First detected in Europe in December 2023 (ACMD 2025), it was characterised by NMR in oils and a herbal product sold in Japan, alongside related propanoate and butanoate esters (Tanaka et al., 2025); in German seizures, acetates mostly appeared only at trace levels (Hundertmark et al., 2025). No receptor measurement, no pharmacokinetic data and no human study have been published for the ester itself; according to the EMCDDA, cannabinoid esters as a rule act as prodrugs of the free phenol. Δ9-THCP binds the human CB1 receptor with a Ki of 1.2 nM, close to that of CP55940, and produced the effects of the cannabinoid tetrad in mice (Citti et al., 2019). A published case describes a psychotic episode after taking 8 mg of Δ9-THCP (Greer et al., 2025). Under vaping conditions, cannabinoid acetates formed ketene, a gas toxic to the lungs (Munger et al., 2022). In France, it falls within the generic class of benzo[c]chromene derivatives.

    Key sources.

    History

    Source
    Semi-synthetic by convention: the acetic ester of Δ9-THCP, which does not occur naturally; found in market products, usually at trace levels

    Route of preparation

    Chemical process

    No biosynthesis: cannabinoids acylated at the phenol do not occur naturally (EMCDDA 2023). THCP-O is the acetic ester of Δ9-THCP, a phytocannabinoid present at trace levels in cannabis (Citti et al., 2019); the origin of the THCP used to make the ester (extract or synthesis) is not documented.

    Classification

    Family, origin and source verification

    Family

    Semi-synthetic cannabinoid › Ester or prodrug

    Chemistry

    C7 side chain · neutral form

    Verification

    Every fact on this entry was checked against its primary sources on 20 October 2026.

    Wikipedia (English)

    THCP-O-acetate (new tab)

    Article paired by the molecule's structure (InChIKey), revision read on 19 October 2026. Read as a second opinion, never cited as a source.

    References

    1. Tanaka R, Ito M, Kikura-Hanajiri R. Identification of Acetyl, Propionyl, and Butanoyl Derivatives of THC and Its Analogs, and Their Synthetic By-Products in Oils and a Herbal Product. Drug Test Anal 2025;17:1795-1802 (new tab)PMID 40075559
    2. Hundertmark M, Besch L, Röhrich J, Germerott T, Wunder C. Characterising a New Cannabis Trend: Extensive Analysis of Semi-Synthetic Cannabinoid-Containing Seizures From Germany. Drug Test Anal 2025;17:1803-1816 (new tab)PMID 40108681
    3. Citti C et al. A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-THC: Δ9-tetrahydrocannabiphorol. Sci Rep 2019;9:20335 (new tab)PMID 31889124
    4. Munger KR, Jensen RP, Strongin RM. Vaping Cannabinoid Acetates Leads to Ketene Formation. Chem Res Toxicol 2022;35:1202-1205 (new tab)PMID 35801872
    5. Bone CC et al. Reviewing the Risk of Ketene Formation in Dabbing and Vaping Tetrahydrocannabinol-O-Acetate. Cannabis Cannabinoid Res 2024;9:e1404-e1409 (new tab)PMID 37466480
    6. Greer D, Atherton J, Girgis J. Psychosis and suicide attempt following a single use of delta-9-tetrahydrocannabiphorol: A case report. PCN Rep 2025;4:e70060 (new tab)PMID 39906186
    7. James KM et al. Δ9-tetrahydrocannabutol, Δ9-tetrahydrocannabihexol, and Δ9-tetrahydrocannabiphorol: the impact of varying alkyl chain length on Δ9-THC analog metabolism. J Anal Toxicol 2026;50:bkag045 (new tab)PMID 42286420
    8. Moody MT, Ringel MM, Mathews CM, Midthun KM. Determination of Cross-Reactivity of Contemporary Cannabinoids with THC Direct Immunoassay (ELISA) in Whole Blood. J Anal Toxicol 2022;46:844-851 (new tab)PMID 35867546
    9. Persson M et al. In vitro activation of the CB1 receptor by HHC, HHC-O and HHC-P. Drug Test Anal 2025;17:487-493 (new tab)PMID 38894658
    10. EMCDDA (Ujváry et al.), Hexahydrocannabinol (HHC) and related substances, technical report, 2023 (§2.6.2; Wolf et al. 2022, conference abstract) (new tab)
    11. ACMD (UK), Semi-synthetic cannabinoids: cannabinoids related to tetrahydrocannabinol and cannabidiol, May 2025 (table 1) (new tab)
    12. ANSM, consolidated list of substances classified as narcotics, updated 26/06/2026 (benzo[c]chromene class, annex IV) (new tab)
    13. PubChem CID 172677450 (Delta9-THCP acetate) (new tab)

    Identifiers

    Names

    Common name
    Tetrahydrocannabiphorol acetate
    IUPAC name
    [(6aR,10aR)-3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-yl] acetate
    Other names
    THCP-O-acetate · THCPO · Delta9-THCP acetate

    Identifiers

    Formula
    C₂₅H₃₆O₃
    CAS
    2829292-82-0
    PubChem CID
    172677450(new tab)
    InChIKey
    OXMUZNKOOOITQD-NHCUHLMSSA-N
    SMILES
    CCCCCCCC1=CC2=C([C@@H]3C=C(CC[C@H]3C(O2)(C)C)C)C(=C1)OC(=O)C

    Machine-readable entry (JSON)

    LLM ingestion format: a structured superset of the entry (identifiers, binding, versioned legal status). Full corpus.

    In the Journal